SPATA2 Antibodies

AND SPATA2 ELISA kits, SPATA2 Proteins

Many biological assays use antibodies to detect SPATA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPATA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPATA2 antibodies...

We validate the specificity of these antibodies to SPATA2 by testing them on tissues known to express SPATA2 positively and negatively. Browse below to find the SPATA2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPATA2 Infographic by Boster Bio

All SPATA2 Products

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SPATA2 (NM_006038) Human Over-expression Lysate

SPATA2 Human Over-expression Lysates NM_001135773

Human

$628
Cat # LS009825
20 µg, 100 µg

Anti-SPATA2 Antibody Picoband®

Western blot analysis of SPATA2 using anti-SPATA2 antibody (A08949-1)

Mouse, Rat

$370
Cat # A08949-1
100 μg/vial

SPATA2 Overview

Facts about Spermatogenesis-associated protein 2.

SPATA2 3D structure. Source: alphafold

Spermatogenesis-associated protein 2 (SPATA2)

Bridging variable that mediates the recruitment of CYLD into the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of this LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD into the TNF- R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049).

Required to activate the'Met-1'- (linear) and'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting'Met-1'- linked deubiquitination of RIPK1 by CYLD (By similarity).

Gene Information

Human
Gene Name:	SPATA2
Uniprot:	Q9UM82
Entrez:	9825

Family

Belongs to:

SPATA2 family

Alternative Names

KIAA0757FLJ13167; PD1spermatogenesis associated PD1; spermatogenesis associated 2; spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1; tamo

Molecular Weight

Mass (kDA):
58.427 kDA

Genomic Context


Human

Location:	20q13.13
Sequence:	20; NC_000020.11 (49903391..49915529, complement)

Tissue Specificity

Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level) (PubMed:10222154, PubMed:11079456). Low expression in spleen, thymus and prostate (PubMed:10222154).

Subcellular Localizations

Cytoplasm. Nucleus. Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells.

Diseases

Nervousness
Psoriasis
Oligospermia
Congenital Absence Of Germinal Epithelium Of Testes
Dermatologic Disorders
Dysequilibrium Syndrome

Interacting Proteins

GOLGA2
LZTS2
MAD1L1
TRIM27

Pathways

Spermatogenesis

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPATA2

References

PMID: 10222154 by Graziotto R., et al. cDNA cloning and characterization of PD1: a novel human testicular protein with different expressions in various testiculopathies.

PMID: 11079456 by Onisto M., et al. A novel gene (PD1) with a potential role on rat spermatogenesis.