Spatacsin Antibodies

AND SPG11 ELISA kits, Spatacsin Proteins

Many biological assays use antibodies to detect Spatacsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Spatacsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Spatacsin antibodies...

We validate the specificity of these antibodies to Spatacsin by testing them on tissues known to express SPG11 positively and negatively. Browse below to find the SPG11 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Spatacsin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SPG11 IHC Guide

SPG11 Infographic by Boster Bio

All SPG11 Products

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Anti-Spatacsin SPG11 Antibody

Western blot analysis of SPG11 in mouse heart tissue lysate with SPG11 antibody at (A) 0

Immunohistochemistry of SPG11 in mouse brain tissue with SPG11 antibody at 2

Human, Mouse, Rat

ELISA, IHC-P, WB

$481
Cat # A03005
0.1 mg

SPG11 Overview

Facts about Spatacsin.

SPG11 3D structure. Source: alphafold

Spatacsin (SPG11)

May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. .

Gene Information

Human
Gene Name:	SPG11
Uniprot:	Q96JI7
Entrez:	80208

Family

Belongs to:

No superfamily

Alternative Names

Colorectal carcinoma-associated protein; FLJ21439spatacsin; KIAA1840DKFZp762B1512; spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11 protein

Molecular Weight

Mass (kDA):
278.868 kDA

Genomic Context


Human

Location:	15q21.1
Sequence:	15; NC_000015.10 (44562696..44663678, complement)

Tissue Specificity

Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons.

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. Cell projection, axon. Cell projection, dendrite. Mainly cytoplasmic.

Diseases

Paraplegia
Spastic Paraplegia
Spastic Paraplegia, Hereditary
Spastic Paraplegia, Hereditary, Autosomal Recessive
Impaired Cognition
Paraparesis
Paraparesis, Spastic
Neurodegenerative Disorders
Atrophy
Muscle Spasticity
Agenesis Of Corpus Callosum

Ataxia
Peripheral Neuropathy
Cognition Disorders
Polyneuropathy
Cerebellar Ataxia

Interacting Proteins

SERTAD3

Pathways

Transport
Dna Repair
Cognition
Localization
Double-strand Break Repair

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPG11

References

PMID: 17322883 by Stevanin G., et al. Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum.

PMID: 18079167 by Stevanin G., et al. Mutations in SPG11 are frequent in autosomal recessive spastic paraplegia with thin corpus callosum, cognitive decline and lower motor neuron degeneration.