Anti-Spatacsin SPG11 Antibody

SPG11 antibody

Boster Bio Anti-Spatacsin SPG11 Antibody (Catalog # A03005). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A03005
Size: 0.1 mg
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, IHC-P, WB

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Product Name

Anti-Spatacsin SPG11 Antibody

View all SPG11 Antibodies

SKU/Catalog Number

A03005

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Spatacsin SPG11 Antibody (Catalog # A03005). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

SPG11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Spatacsin SPG11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03005)

Host

Rabbit

Contents

SPG11 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SPG11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPG11. The immunogen is located within amino acids 2360 - 2410 of SPG11.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03005 is reactive to SPG11 in Human, Mouse, Rat

Applications

A03005 is guaranteed for ELISA, IHC-P, WB Boster Guarantee

Background of SPG11

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.  Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

SPG11 antibody can be used for detection of SPG11 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Validation Images & Assay Conditions

Gene/Protein Information For SPG11 (Source: Uniprot.org, NCBI)

Uniprot ID

Q96JI7

Gene ID

80208

Gene Name

SPG11

Full Name

Spatacsin

Weight

278.868kDa

Alternative Names

Colorectal carcinoma-associated protein; FLJ21439spatacsin; KIAA1840DKFZp762B1512; spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11 protein SPG11 ALS5, CMT2X, KIAA1840 SPG11 vesicle trafficking associated, spatacsin spatacsin|SPG11, spatacsin vesicle trafficking associated|amyotrophic lateral sclerosis 5|colorectal carcinoma-associated protein|spastic paraplegia 11 (autosomal recessive)|spastic paraplegia 11 protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SPG11, check out the SPG11 Infographic

SPG11 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SPG11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

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Size

Total: $404

SKU:A03005

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Ships directly to USA and Canada. For other regions, visit our distributors page

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A03005
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$404.00

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