Paraplegin Antibodies

AND SPG7 ELISA kits, Paraplegin Proteins

Many biological assays use antibodies to detect Paraplegin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Paraplegin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Paraplegin antibodies...

We validate the specificity of these antibodies to Paraplegin by testing them on tissues known to express SPG7 positively and negatively. Browse below to find the SPG7 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SPG7 Infographic by Boster Bio

All SPG7 Products

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Anti-Paraplegin SPG7 Antibody

Western blot analysis of extracts of various cell lines, using SPG7 antibody at 1:1000 dilution

Human, Mouse, Rat

IHC, WB

$405
Cat # A04104
100ul

Anti-SPG7 Mouse Monoclonal Antibody [Clone ID: OTI1D3]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SPG7 (Right lane) cDNA for 48 hrs and lysed

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-SPG7 mouse monoclonal antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-SPG7 mouse monoclonal antibody

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M04104
100 µl

Anti-SPG7 Mouse Monoclonal Antibody [Clone ID: OTI1C1]

Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-SPG7 monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen)

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-SPG7 monoclonal antibody

Dog, Human, Monkey, Mouse, Rat

Flow Cytometry, IF, WB

$523
Cat # M04104-1
100 µl

SPG7 (NM_003119) Human Over-expression Lysate

Human

$628
Cat # LS006687
20 µg, 100 µg

SPG7 Overview

Facts about Paraplegin.

SPG7 3D structure. Source: alphafold

Paraplegin (SPG7)

ATP-dependent zinc metalloprotease. Plays a role in the creation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (PubMed:26387735).

Gene Information

Human
Gene Name:	SPG7
Uniprot:	Q9UQ90
Entrez:	6687

Family

Belongs to:

No superfamily

Alternative Names

CARMGC126331; cell matrix adhesion regulator; CMARMGC126332; EC 3.4.24; EC 3.4.24.-; FLJ37308; paraplegin; PGNcell adhesion regulator; spastic paraplegia 7 (pure and complicated autosomal recessive); Spastic paraplegia 7 protein; SPG5C

Molecular Weight

Mass (kDA):
88.235 kDA

Genomic Context


Human

Location:	16q24.3
Sequence:	16; NC_000016.10 (89508379..89557768)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Mitochondrion inner membrane; Multi-pass membrane protein.

Diseases

Spastic Paraplegia, Hereditary
Paraplegia
Spastic Paraplegia
Neurodegenerative Disorders
Atrophy
Paraparesis
Paraparesis, Spastic
Aortic Aneurysm, Abdominal
Ataxia
Muscle Spasticity
Mitochondrial Diseases

Optic Atrophy
Nerve Degeneration
Impaired Cognition
Weakness
Spastic Paraplegia, Hereditary, Autosomal Recessive
Optic Atrophy, Autosomal Dominant

Interacting Proteins

CCNDBP1
HNRNPK
KHDRBS2
KRT40
KRTAP10-7

KRTAP10-9
LZTS2
MDFI
MTUS2
NOTCH2NL

PNMA1
PSME3
PSTPIP1
RBPMS

Pathways

Pathogenesis
Oxidative Phosphorylation
Ribosome Assembly
Translation
Transport
Proteolysis
Localization
Cell Adhesion
Induction Of Apoptosis
Brain Development
Mastication
Membrane Fusion
Mitochondrial Fusion

Regeneration
Reverse Transcription
Cell Death
S Phase
Mitochondrial Translation
Cognition
Protein Import

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPG7

References

PMID: 9635427 by Casari G., et al. Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease.

PMID: 10480368 by Settasatian C., et al. Genomic structure and expression analysis of the spastic paraplegia gene, SPG7.