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- Table of Contents
SPIB Antibodies
AND SPIB ELISA kits, SPIB Proteins
Many biological assays use antibodies to detect SPIB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPIB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPIB antibodies...
Designing a Western blot for SPIB? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPIB Western Blot GuideDesigning an IHC experiment for SPIB? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SPIB IHC GuideSPIB Infographic by Boster Bio
All SPIB Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A02805-1
0.1 mg
Cat # A02805-1
0.1 mg
SPIB Overview
Facts about Transcription factor Spi-B.
Transcription factor Spi-B (SPIB)
Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also called type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells.
These cells have the capacity to produce large quantities of interferon and prevent viral replication. May be necessary for B-cell receptor (BCR) signaling, which is vital for normal B-cell development and antigenic stimulation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SPIB |
| Uniprot: | Q01892 |
| Entrez: | 6689 |
Family
| Belongs to: |
|---|
| ETS family |
Alternative Names
Spi-B transcription factor (Spi-1/PU.1 related); SpiB; Spi-B; transcription factor Spi-B
Molecular Weight
Mass (kDA):
28.819 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.33 |
| Sequence: | 19; NC_000019.10 (50418938..50431314) |
Tissue Specificity
Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
Subcellular Localizations
[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
Diseases
- Liver Cirrhosis
- Leukemia
- Burkitt Lymphoma
- Biliary Cirrhosis
- Primary Biliary Cirrhosis
- Malignant Neoplasms
- Neoplasms
- Lymphoma
- Diffuse Large B-cell Lymphoma
- B-cell Lymphomas
- Malignant Paraganglionic Neoplasm
- Precursor B-cell Lymphoblastic Leukemia-lymphoma
- Liver Diseases
Pathways
- Cell Differentiation
- Cell Development
- B Cell Differentiation
- Immune Response
- Pathogenesis
- Rna Interference
- Germinal Center Formation
- Adaptive Immune Response
- T Cell Lineage Commitment
- Interferon-gamma Production
- Tube Formation
- Neurogenesis
- Plasma Cell Differentiation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPIB
bosterbio.com/bosterbio-gene-info-cards/SPIB
References
PMID: 1406622 by Ray D., et al. Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.
PMID: 8670269 by Ray-Gallet D., et al. An alternatively spliced isoform of the Spi-B transcription factor.