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- Table of Contents
STIM1 Antibodies
AND STIM1 ELISA kits, STIM1 Proteins
Many biological assays use antibodies to detect STIM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with STIM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop STIM1 antibodies...
Designing a Western blot for STIM1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the STIM1 Western Blot GuideSTIM1 Infographic by Boster Bio
All STIM1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9406
100 μg/vial
Cat # PB9406
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A00312-1
100 µg/vial
Cat # A00312-1
100 µg/vial
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M00312
100 μl
Cat # M00312
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00312-2
20μL, 40μL, 100μL, 200μL
Cat # M00312-2
20μL, 40μL, 100μL, 200μL
Human
$628
Cat # LS006786
20 µg, 100 µg
Cat # LS006786
20 µg, 100 µg
STIM1 Overview
Facts about Stromal interaction molecule 1.
Stromal interaction molecule 1 (STIM1)
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:15866891, PubMed:16005298, PubMed:16208375, PubMed:16537481, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:18854159, PubMed:19249086, PubMed:22464749, PubMed:24069340, PubMed:24351972, PubMed:24591628, PubMed:26322679, PubMed:25326555, PubMed:28219928).
Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domainname.Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed:16208375, PubMed:16537481). Involved in enamel formation (PubMed:24621671).
Gene Information
| Human | |
|---|---|
| Gene Name: | STIM1 |
| Uniprot: | Q13586 |
| Entrez: | 6786 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
GOK; GOKD11S4896E; STIM1; stromal interaction molecule 1
Molecular Weight
Mass (kDA):
77.423 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (3855664..4093210) |
Tissue Specificity
Ubiquitously expressed in various human primary cells and tumor cell lines.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Sarcoplasmic reticulum. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane (PubMed:19249086, PubMed:16005298, PubMed:16208375, PubMed:18854159). Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Colocalizes with ORAI1 at the ce
Diseases
- Neoplasms
- Malignant Neoplasms
- Immunologic Deficiency Syndromes
- Autoimmune Reaction
- Autoimmunity
- Thrombosis
- Autoimmune Diseases
- Severe Combined Immunodeficiency
- Diabetes Mellitus
- Vascular System Injuries
- Inflammation
- Hypertrophy
- Cell Transformation, Neoplastic
Interacting Proteins
- CRACR2A
- ORAI1
- PDIA3
- STIM2
- TRPC1
Pathways
- Store-operated Calcium Entry
- Localization
- Cell Proliferation
- Secretion
- Rna Interference
- Pathogenesis
- Cell Activation
- Cell Migration
- Platelet Activation
- Immune Response
- T Cell Activation
- Lymphocyte Activation
- Muscle Contraction
PTMs
- Phosphorylation
- Glycosylation
- Biotinylation
- Cleavage
Research Areas
- Cancer
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STIM1
bosterbio.com/bosterbio-gene-info-cards/STIM1
References
PMID: 8921403 by Parker N.J., et al. Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5.
PMID: 9377559 by Sabbioni S., et al. GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development.
1 Publications of Boster STIM1 Antibodies & ELISA Kits
- PubMed ID: 10.1186/s40478-017-0427-7, Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stres...
*More publications can be found for each product on its corresponding product page