Stathmin Antibodies

Stathmin (STMN1)

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules.

Phosphorylation at Ser- 16 could be necessary for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

Gene Information

Human
Gene Name:	STMN1
Uniprot:	P16949
Entrez:	3925

Family

Belongs to:
stathmin family

Alternative Names

C1orf215; chromosome 1 open reading frame 215; Lag; Leukemia-associated phosphoprotein p18; metablastin; MGC138869; Oncoprotein 18; Op18; OP18MGC138870; phosphoprotein 19; Phosphoprotein p19; PP17; PP19; PR22; prosolin; Protein Pr22; SMNLAP18FLJ32206; stathmin 1; stathmin 1/oncoprotein 18; stathmin; transmembrane protein C1orf215

Molecular Weight

Mass (kDA):
17.303 kDA

Genomic Context

Human
Location:	1p36.11
Sequence:	1; NC_000001.11 (25884179..25906877, complement)

Tissue Specificity

Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.

Subcellular Localizations

Cytoplasm, cytoskeleton.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Leukemia
• Neoplasm Metastasis
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Hyperplasia
• Cell Invasion
• Tissue Adhesions
• Malignant Paraganglionic Neoplasm
• Nervousness
• Cell Transformation, Neoplastic

• Lymphoma
• Acute Erythroblastic Leukemia
• Carcinogenesis
• Malignant Neoplasm Of Prostate
• Adenocarcinoma
• Prostatic Neoplasms
• Malignant Neoplasm Of Lung

Interacting Proteins

• CDKN1B
• SESTD1

Pathways

• Cell Cycle
• Cell Proliferation
• Mitosis
• Cell Growth
• Interphase
• Localization
• Cell Division
• Cell Migration
• Pathogenesis
• Cell Adhesion
• Cell Death
• Cell Differentiation
• Cell Motility

• Rna Interference
• Regeneration
• Aging
• S Phase
• Microtubule Polymerization
• Translation
• Spindle Assembly

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation
• Methylation

• Reduction
• Deacetylation
• Acetylation
• Prenylation

Research Areas

• Breast Cancer
• Cancer
• Immunology
• Microglia Markers
• Neuroscience

• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STMN1

Boster Bio - Best Uses Of The STMN1 Marker

This article will discuss Boster Bio's most important uses and provide an inside look at its capabilities. We'll also discuss why Stathmin-1 is a superior indicator of squamous-cell cancer. We'll also discuss the benefits of this marker, such as lower detection limits and custom-designed services. Let's move on to the good stuff first.

AlphaLISA also has some other advantages.

The AlphaLISA proximity assay is a based on a bead which utilizes oxygen channeling technology. A blue bead that contains Phthalocyanine is activated by a 680nm laser. This causes ambient oxygen to transform into singlet oxygen. Approximately 60,000 singlet oxygen molecules are created in the water sample. The singlet oxygen molecules react with the Acceptor beads, causing an luminescent reaction. The Acceptor beads contain a substance containing Europium. They emit intense luminescence that is 615 nanometers.

The AlphaLISA method provides the benefit of no-washing and an ultra-fast high-throughput screening tool. It also works well for small-volume samples. There are many other advantages to the system. Let's take a look at some of them below. Its ability to detect SAs in a broad range of samples indicates that it is an excellent choice for applications that require fast and precise analysis. The AlphaLISA method has been used to detect SAs in plasma and milk and pork, chicken and fish, as well as plasma.

AlphaLISA is a multi-faceted technique allows for the quantification and analysis of secreted, intracellular and cell membrane proteins. It is a sandwich-based immunoassay that employs a biotinylated antibody to interact with a donor and acceptor beads with an absorbent. It emits an intense, spectrally-defined emission that is suitable for automated fluid dispensing systems as well as detection systems.

A cell-based approach yields more relevant and accurate results than a bead-based one. For example, SAs monoclonal antibody binds to cells on a surface. High-throughput flow cytometry platforms allow researchers to generate more relevant data in less time which is ideal for high-throughput antibody discovery programs. This method reduces resource requirements and increases the accuracy of.

Stathmin-1 is a more reliable serological marker for squamous cell carcinoma.

The study suggests that serum stathmin levels could be a better biomarker for squamous cell cancer than CKMB-1 on its own. However, the amount of stathmin was also higher with the clinical stage. Although further studies are required to confirm these findings, stathmin serum levels could provide a better biomarker of ESCC.

This study is designed to determine whether stathmin is a more effective biomarker for ESCC than CT-MB-1. Two-dimensional gel electrophoresis (DGE) was used by the researchers to examine global gene expression profiles. The stathmin levels of expression were significantly different in both groups. Of the 63 upregulated genes nineteen were functionally enhanced in extracellular components.

The study examined serum samples from patients suffering from cancer confirmed by pathology and healthy subjects. The serum samples of patients suffering from colorectal, gastric, and hepatocellular cancers were also collected. A panel of three to four TAAs could be more reliable than a single marker.

In another study, overexpression of stathmin in ESCC increased the cell's movement and adhesion to the extracellular matrix. Studies have shown that stathmin's overexpression can cause tumor metastasis. Stathmin overexpression in mice promoted lung metastasis. Moreover, the expression of integrina5b1–FAK gene mediated increased ERK pathway activation, as well as cell adhesion to the extracellular matrix.

It has a lower detection limit.

The term "limits of detection" can be used to describe any scientific disciplines. There are many ways to address this issue. For example, chemical measurements have the most precise definitions as well as methods to limit detection. Biochemical tests and experiments are more complex and are based on a variety of variables which include false positives as well as false negatives. Geochemistry isn't an exception.

The Lower Limit of Detection is the lowest concentration of a certain chemical in a sample. In other words, this limit is the smallest amount of this substance that can be identified without creating harm. LLDs typically exceed the upper limit of detection. This is because of the varying nature of chemical reactions and the complexity of detection methods. Therefore, it is essential to determine the lower limit of detection prior to conducting a test.

The detection limit is the minimum concentration of analyte that is accurately detected by a particular analytical technique. It is also referred to as the analytic sensitivity. In essence, it is the lowest concentration of analyte that can be distinguished statistically from a blank. It is also a crucial aspect to consider when interpreting results. It is vital to know the lower limit and its implications in order to finish the project in a timely manner.

The lower limit of detection (LoD) is the lowest concentration of analyte that is measurable with 99% confidence. In certain instances however, the sample's actual concentration may be greater than the LoD. In these situations the LoQ must be set after the specimen has been analysed at a level higher than the LoD. This assures that the sample does not exceed the upper limit for detection.