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TET2 Antibodies
AND TET2 ELISA kits, TET2 Proteins
Many biological assays use antibodies to detect TET2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TET2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TET2 antibodies...
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TET2 Overview
Facts about Methylcytosine dioxygenase TET2.
Methylcytosine dioxygenase TET2 (TET2)
Dioxygenase that catalyzes the conversion of this modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs.
Also mediates following conversion of 5hmC into 5- formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC to 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | TET2 |
| Uniprot: | Q6N021 |
| Entrez: | 54790 |
Family
| Belongs to: |
|---|
| TET family |
Alternative Names
FLJ20032; MGC125715; tet methylcytosine dioxygenase 2
Molecular Weight
Mass (kDA):
223.811 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q24 |
| Sequence: | 4; NC_000004.12 (105145875..105279803) |
Tissue Specificity
Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
Diseases
- Leukemia
- Neoplasms
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Dysmyelopoietic Syndromes
- Myeloproliferative Disease
- Malignant Neoplasms
- Leukemia, Myelomonocytic, Chronic
- Primary Myelofibrosis
- Thrombocytosis
- Myelomonocytic Leukemia
- Polycythemia Vera
Interacting Proteins
- OGT
- PML
Pathways
- Pathogenesis
- Methylation
- Dna Methylation
- Demethylation
- Dna Demethylation
- Dna Modification
- Metaphase
- Regulation Of Gene Expression
- Dna Hypermethylation
- Aging
- Histone Modification
- Cell Cycle
- Interphase
PTMs
- Methylation
- Demethylation
- Hydroxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TET2
bosterbio.com/bosterbio-gene-info-cards/TET2
References
PMID: 12880961 by Ohira M., et al. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.
PMID: 12646957 by Lorsbach R.B., et al. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).