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Product Info Summary
| SKU: | A00191-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-TET2 Antibody
SKU/Catalog Number
A00191-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TET2 Antibody (Catalog # A00191-1). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TET2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00191-1)
Host
Rabbit
Contents
TET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TET2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET2. The immunogen is located within amino acids 1550 - 1600 of TET2.
Cross-reactivity
TET2 antibody is human and mouse reactive. At least two isoforms of TET2 are known to exist; this antibody will detect the larger isoforms. This antibody is predicted to not cross-react with TET1 and TET3.
Reactive Species
A00191-1 is reactive to TET2 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
223.8 kDa
Background of TET2
TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2). Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00191-1 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TET2 antibody can be used for detection of TET2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TET2 in 3T3 cell lysate with TET2 antibody at 1 μg/ml.
Specific Publications For Anti-TET2 Antibody (A00191-1)
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