This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
1 Citations 7 Q&As
Facts about Tissue factor pathway inhibitor 2.
Has no effect on thrombin. .
Human | |
---|---|
Gene Name: | TFPI2 |
Uniprot: | P48307 |
Entrez: | 7980 |
Belongs to: |
---|
No superfamily |
Placental protein 5; PP5; PP5FLJ21164; REF-1; TFPI2; TFPI-2; TFPI-2REF1; tissue factor pathway inhibitor 2
Mass (kDA):
26.934 kDA
Human | |
---|---|
Location: | 7q21.3 |
Sequence: | 7; NC_000007.14 (93885396..93890753, complement) |
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
Secreted.
If you're struggling to optimize your Boster Bio, you've come to the right location. Check out our guide to the TFPI2 marker to find out how you can get the most of this vital biomarker. You'll be able to identify common problems and get the most out of your research. These are some helpful tips and tricks to optimize your Boster Bio.
Common tyrosine-kinase inhibition inhibitor The TFPI2 marker is a great choice for many reasons. It is a highly specific antibody and is compatible with various cell types including MDAMB-453 (MCF7). It is sensitive and is able to detect small amounts TFPI2 within the samples. BosterBio must be optimized using the TFPI2 marker.
The TFPI2 marker is a promising way to identify asymptomatic VTE patients suffering from EOC. It is not yet accessible in the US but the Japanese national insurance system will cover the test beginning in April 2021. At the time of this writing, there have not been any clinical trials for TFPI2 EOC. A 2014 study found that patients with CCC had significantly higher levels of TFPI2 than those who did not have CCC.
The D-dimer is a marker which is associated with TFPI2 levels. This marker was measured in plasma using a DD immunoenzymometric assay kit. The cutoff value was 1.0 Ug/ml. Two Tosoh diagnostics product groups used an AIA PACK TFPI2 assay kit and an AIA 2000 immunoassay kit that measures the TFPI2 marker. The results of both studies demonstrated high intra - and inter-assay variation.
Numerous studies have revealed that TFPI2 may enhance the ability of D-dimer to detect the presence of asymptomatic liver disease. A previous study demonstrated that TFPI2 gene expression was greater in patients with hepatocellular tumors than in healthy people. Two-step screening with a D-dimer marker and TFPI2 marker may reduce the burden of ultrasound specialists.
The effects of TFPI2 on angiogenesis growth are independent of the proliferation. In addition to its effect on EC proliferative activity, TFPI2 inhibits a range of proteases, including MMPs and plasmin. These factors protect the extracellular matrix from damage and also prevent EC invasion and metastasis. Tissue factor pathway inhibitor 2 could be involved in the suppression of malignant tumors.
TFPI2 is associated with pathways that are involved in the human papillomavirus infection. This gene is also linked to pathways that involve calcium signaling and cytokine cytokine receptor interactions and TNF signaling. Furthermore, TFPI2 may be a important biomarker for melanoma research. A clinical study could be conducted with these findings to determine whether TFPI2 can be used to predict the progression of cancer.
The TFPI2 marker being used in coronary arteries with atherosclerosis could identify a link between the development of atherosclerosis and vascular remodelling. The gene is expressed in endothelial cells of the atherosclerotic arterial and its abnormal regulation is linked to atherogenesis. The expression of TFPI-2 in atherosclerotic vessels is compared with the expression of the TFPI2 gene in healthy arterial.
PMID: 7896752 by Miyagi Y., et al. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2.
PMID: 8159751 by Sprecher C.A., et al. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor.
*More publications can be found for each product on its corresponding product page