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Facts about Transforming growth factor beta-2 proprotein.
Human | |
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Gene Name: | TGFB2 |
Uniprot: | P61812 |
Entrez: | 7042 |
Belongs to: |
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TGF-beta family |
BSC-1 cell growth inhibitor; cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; polyergin; TGFB2; TGFbeta 2; TGF-beta 2; TGF-beta2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor, beta 2
Mass (kDA):
47.748 kDA
Human | |
---|---|
Location: | 1q41 |
Sequence: | 1; NC_000001.11 (218345284..218444619) |
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix.; [Transforming growth factor beta-2]: Secreted.
This article provides information about the TGFB2 marker as well as an explanation of its features and applications. This article includes information about the marker as well as links to educational resources. Boster Bio also offers free PDFs for educators. These documents can be shared with students and educators however, attribution as well as the URL to the source should be provided. The TGFB2 marker is a reversible fluorescent protein that targets the TGFB2 genes, is referred to as TGFB2.
Boster Bio's Anti-TGF beta 2 TGFA2 marker is a powerful treatment for tumors using immunotherapy. The SMAD7 gene has been linked with the growth of tumor cells. It also stimulates transforming growth factor beta signaling by binding to adaptors TAB2 or TAB3. These genes activate TGF betaRI by activating TAK1 and TAK2. The resultant signaling pathway triggers tumor metastasis and progression.
The TGF-b signaling pathway plays a crucial role to a myriad of important cell functions. It regulates cell growth, differentiation and motility, as also apoptosis and invasion. Recent advances in cell biology have produced an extensive list of programs that are controlled by TGF-b. The fact that TGF-b is context-dependent signaling results from the fact that TGF signaling regulates different processes in the cell. A series of signals determines whether a cell will differentiate or develop into invasive or metastatic.
Molecularly targeted therapies play an important part in the field of cancer research. They target the causes of lesions that are oncogenic and the tumor-permissive stroma. TGF-bs are a pleiotropic growth factors and are associated with poor prognosis. Therefore, targeting them could have multiple advantages. The agents that cause cancer might be more efficient if they are blocked.
The anti-TGF beta 2/ TGFB2-Marker at Boster Bio is an effective treatment for cancer that is based on immunotherapy. It can detect TGFb that is active and total in the tumor. It also can stimulate tumor growth and proliferation. The antibody, unlike other immunotherapies works by affecting both of these factors. It is available at Boster Bio and other vendors.
TGFBR2 is a crucial endogenous factor that regulates microglia. In the adult CNS, proper functioning of microglia depends on the TGFb signalling. It has been shown to be an important immunoregulatory protein for microglia in vivo as well as in vitro. Moreover, its overexpression leads to several physiological and pathological effects, including neurodegeneration.
TGF-b2 levels which are high in people with glioma have been linked to the autoimmune diseases. It stimulates muscle growth and neurogenesis. It is a crucial protein in many different diseases, and the range of the TGFB2 marker is wide and includes a variety of biomarkers as well as tests. The range of markers available is also wide.
TGFb-2 can be found in many tissues. It regulates the growth of bone, muscle tissue development and body fat development. It is also crucial in wound healing, immune system function and the development of the skeletal muscle. It is located in tissues that comprise the skeleton, like the skin, the heart stomach, intestine, and. It also creates a complex lattice of cells.
By using this gene scientists can further study the relationship between TGFb-b2 and miRNAs. The miRNA-gene interactions that these genes form may be associated with a distinct set of clinical characteristics, which may serve as new targets for further research. These tests are part of the TGFB2 product range:
The TGFb-2 protein plays many functions throughout the body. The protein regulates the development of blood vessels and muscle tissue. It also plays an important role in healing from wounds and in the immune system. The tissues that comprise the skeleton house the most abundant protein forms. The protein is responsible for bone growth and formation and forms a complex lattice between cells. It is useful in many clinical settings because it is involved in a variety of aspects a cell's lives.
The TGFB family of cytokines is involved in cell proliferation, differentiation, adhesion, migration, and many other functions. This pathway has been implicated in many human cancers. The TGFB/SMAD pathway is thought to disrupt the interleukin-2-dependent growth of T cells. It also is involved in the development of Peters"anomaly," an inheritable form of leukemia.
TGF-b2 expression can be measured by measuring the expression of TGF-b2 in cancer cells. This protein is a regulator for hematopoiesis. It is identified with an easy test of gene expression. Researchers have discovered a new molecular marker for TGF-b2, called the TGFB2 gene. Its affinity for TGF-b2 is high. increases the expression of other hemopoietic factors.
Inflammatory cells release TGF-b-ligands to stimulate ECM deposition. The cells move towards tissues that are damaged, and they promote ECM deposition and accelerate the profibrotic response. The results from these studies suggest that the TGF-b2 hormone promotes the process of fibrosis in human lung tissue as well as other tissues. In addition to its role in fibrosis and inflammation, TGF-b regulates the expression levels of various genes involved in fibrosis.
The TGFB2 marker is a gene that is located on chromosome 19 in humans. The gene is believed be involved in atherosclerosis, bone disease and other conditions. It could also be a candidate gene for DiGeorge syndrome. This gene has been linked to a number of cancers and other diseases. Numerous studies have linked TGFB2 genes to specific diseases such as diabetes and cancer.
You've found the best TGFB2 anti-body. TGFB2 is a receptor for TGF-beta. This antibody is part the Boster Bio Picoband(tm). Boster Bio has antibodies that interact with the receptor in a variety of animal samples. Boster Bio uses rabbit and mouse to develop their antibodies.
PMID: 3322813 by de Martin R., et al. Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.
PMID: 3162414 by Madisen L., et al. Transforming growth factor-beta 2: cDNA cloning and sequence analysis.
*More publications can be found for each product on its corresponding product page