TM9SF4 Antibodies

AND TM9SF4 ELISA kits, TM9SF4 Proteins

Many biological assays use antibodies to detect TM9SF4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TM9SF4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TM9SF4 antibodies...

We validate the specificity of these antibodies to TM9SF4 by testing them on tissues known to express TM9SF4 positively and negatively. Browse below to find the TM9SF4 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TM9SF4 Infographic by Boster Bio

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TM9SF4 (NM_014742) Human Over-expression Lysate

Human

$960
Cat # LS009777
20 µg, 100 µg

TM9SF4 Overview

Facts about Transmembrane 9 superfamily member 4.

TM9SF4 3D structure. Source: alphafold

Transmembrane 9 superfamily member 4 (TM9SF4)

Associates with proteins harboring glycine-rich transmembrane domains and ensures their effective localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576).

Plays an important part in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). .

Gene Information

Human
Gene Name:	TM9SF4
Uniprot:	Q92544
Entrez:	9777

Family

Belongs to:

nonaspanin (TM9SF) (TC 9.A.2) family

Alternative Names

KIAA0255dJ836N17.2; transmembrane 9 superfamily member 4; transmembrane 9 superfamily protein member 4

Molecular Weight

Mass (kDA):
74.519 kDA

Genomic Context


Human

Location:	20q11.21
Sequence:	20; NC_000020.11 (32109714..32167258)

Tissue Specificity

Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level).