TBC1 domain family member 5 (TBC1D5)

May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A.

Can displace RAB7A and retromer CSC subcomplex in the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity.