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3 Citations 9 Q&As
1 Citations 7 Q&As
Facts about Tumor necrosis factor receptor superfamily member 8.
Receptor for TNFSF8/CD30L.
May play a role in the regulation of cellular growth and transformation of activated lymphoblasts.Regulates gene expression through activation of NF- kappa-B. .
Human | |
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Gene Name: | TNFRSF8 |
Uniprot: | P28908 |
Entrez: | 943 |
Belongs to: |
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TNFR8 family |
CD30 antigen; CD30; CD30KI-1; CD30L receptor; cytokine receptor CD30; D1S166EKi-1; Ki-1 antigen; Lymphocyte activation antigen CD30; TNFRSF8; tumor necrosis factor receptor superfamily member 8; tumor necrosis factor receptor superfamily, member 8
Mass (kDA):
63.747 kDA
Human | |
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Location: | 1p36.22 |
Sequence: | 1; NC_000001.11 (12063303..12144213) |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm.
The CD30/TNFRSF8 Protein can be described as a Baculovirus with His-Tag and carries the sequence domain that spans from 19 to 379 aa. The product can be used for SDS-PAGE. It is recommended to store the product between temperatures between -20 and +80degC. Be aware that this product is not tested for use in applications with low temperatures. Scientists who publish their findings receive product credits that can be used for any Boster product. Researchers from all over the globe have access to these product credits for free.
The TNFRSF8 marker acts as a powerful inhibitor of immunity. The TNFRSF17 bispecific anti-TNFRSF17 EM801 activates IL-15 receptors on NK cells. This activates perforin expression, cytotoxicity and the granzyme B production. This protein is also believed to stimulate macrophages and promote the growth of tumor cells.
Anti-CD153/TNFSF8 acts as an antigen on the cell's surface. It is a well-known marker for Hodgkin lymphoma, as well as other hematologic malignancies. It is linked to the inhibition or the Ig class switch and is a marker of growth and immune function. These markers have multiple therapeutic uses.
The mouse CD153 is the ligand for TNFSF8/CD30. a cell surface antigen that is expressed by activated T B, T, and monocyte cells. The binding of this ligand to the receptor TNFRSF8/CD30 blocks the switching of Ig class to Non-Th2 immune responses. It also reduces the proliferation of cells in lymphoma cell lines which suggests that it plays an pleiotropic role in the pathology.
Scientists are now beginning to understand the mechanisms behind the CD30 signaling process by studying its role in the vivo. The CD30 ligand mediates degranulation-independent chemokine secretion and enhances the ability of T cells to produce allografts. By interacting with the TNFRSF8 receptor the CD30 ligand aids in the creation of regulatory T cells which are vital in the immune system.
In this study, sCD30 was found to have a positive effect on the survival of transplants over 3 years, but not on acute rejection episodes. To determine sCD30 levels the serum samples were collected from 183 patients who had received transplants. A cutoff level of 100 U/mL was utilized to distinguish between the two groups. Patients with immunological graft rejection had a significantly higher sCD30 level.
Researchers have discovered that ginger bioactive substances increase the ratio of CD3+CD4+ and CD3+CD8+ T cells. Researchers found that sonicating ginger increased the ratio of CD3+CD8+ to T-cells using this bioactive ligand. The ginger bioactive components also inhibited TNFRSF8/CD30.
PMID: 1310894 by Duerkop H., et al. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease.
PMID: 7527901 by Jung W., et al. Opposite effects of the CD30 ligand are not due to CD30 mutations: results from cDNA cloning and sequence comparison of the CD30 antigen from different sources.
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