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- Table of Contents
Tripeptidyl-peptidase 1 Antibodies
AND TPP1 ELISA kits, Tripeptidyl-peptidase 1 Proteins
Many biological assays use antibodies to detect Tripeptidyl-peptidase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tripeptidyl-peptidase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tripeptidyl-peptidase 1 antibodies...
Designing a Western blot for Tripeptidyl-peptidase 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the TPP1 Western Blot GuideDesigning an IHC experiment for Tripeptidyl-peptidase 1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the TPP1 IHC GuideTPP1 Infographic by Boster Bio
All TPP1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK2042
96 wells/kit, with removable strips.
Cat # EK2042
96 wells/kit, with removable strips.
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00103-1
100 μg/vial
Cat # A00103-1
100 μg/vial
TPP1 Overview
Facts about Tripeptidyl-peptidase 1.
Tripeptidyl-peptidase 1 (TPP1)
Lysosomal serine protease with tripeptidyl-peptidase I action. May act as a non invasive lysosomal peptidase which generates tripeptides from the breakdown products created by lysosomal proteinases.
Requires substrates having an unsubstituted N-terminus (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | TPP1 |
| Uniprot: | O14773 |
| Entrez: | 1200 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cell growth-inhibiting gene 1 protein; ceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease); CLN2; CLN2EC 3.4.14.9; growth-inhibiting protein 1; LINCL; LPIC; lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP1; TPP-1; TPP-I; Tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; TripeptidylPeptidase I; Tripeptidyl-Peptidase I
Molecular Weight
Mass (kDA):
61.248 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (6612768..6619422, complement) |
Tissue Specificity
Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Subcellular Localizations
Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Diseases
- Neuronal Ceroid-lipofuscinoses
- Late-infantile Neuronal Ceroid Lipfuscinosis
- Malignant Neoplasms
- Infantile Neuronal Ceroid Lipofuscinosis
- Neurodegenerative Disorders
- Neoplasms
- Nerve Degeneration
- Telomere Shortening
- Nervousness
- Lysosomal Storage Diseases
- Blind Vision
- Ataxia
Interacting Proteins
- STN1
- TERT
Pathways
- Telomere Maintenance
- Pathogenesis
- Localization
- Dna Repair
- Senescence
- S Phase
- Cell Cycle
- Telomere Binding
- Rna Interference
- Transport
- Aging
- Segmentation
- Telosome Assembly
PTMs
- Cleavage
- Glycosylation
- Oxidation
Research Areas
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPP1
bosterbio.com/bosterbio-gene-info-cards/TPP1
References
PMID: 9295267 by Sleat D.E., et al. Association of mutations in a lysosomal protein with classical late- infantile neuronal ceroid lipofuscinosis.
PMID: 9653647 by Liu C.-G., et al. Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis.