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- Table of Contents
TRPC3 Antibodies
AND TRPC3 ELISA kits, TRPC3 Proteins
Many biological assays use antibodies to detect TRPC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPC3 antibodies...
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TRPC3 Infographic by Boster Bio
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TRPC3 Overview
Facts about Short transient receptor potential channel 3.
Short transient receptor potential channel 3 (TRPC3)
Thought to form a receptor-activated non-selective calcium permeant cation channel. Likely is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPC3 |
| Uniprot: | Q13507 |
| Entrez: | 7222 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
hTrp3; hTrp-3; short transient receptor potential channel 3; transient receptor potential cation channel, subfamily C, member 3; transient receptor potential channel 3; Transient receptor protein 3; TRP3; TRP-3; TrpC3
Molecular Weight
Mass (kDA):
96.009 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q27 |
| Sequence: | 4; NC_000004.12 (121874481..121952060, complement) |
Tissue Specificity
Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.
Subcellular Localizations
Membrane; Multi-pass membrane protein.
Diseases
- Hypertensive Disease
- Hypertrophy
- Cardiac Hypertrophy
- Pathologic Vasoconstriction
- Malignant Neoplasms
- Nervousness
- Hypoxia
- Cardiovascular Diseases
- Heart Failure
- Pain
- Stenosis
- Neoplasms
Interacting Proteins
- ITPR3
- MX1
- ORAI1
- Plcg1
- Src
- Wnk4
Pathways
- Localization
- Vasoconstriction
- Cell Proliferation
- Pathogenesis
- Membrane Depolarization
- Rna Interference
- Secretion
- Store-operated Calcium Entry
- Cell Death
- Transport
- Synaptic Transmission
- Gene Silencing
- Angiogenesis
PTMs
- Phosphorylation
- Biotinylation
- Glycosylation
- Cleavage
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPC3
bosterbio.com/bosterbio-gene-info-cards/TRPC3
References
PMID: 8646775 by Zhu X., et al. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
PMID: 9215637 by Xu X.-Z.S., et al. Coassembly of TRP and TRPL produces a distinct store-operated conductance.
1 Publications of Boster TRPC3 Antibodies & ELISA Kits
- PubMed ID: 32844288, Wang Y,Liu L,Tao H,Wen L,Qin S.TRPC6 participates in the development of blood pr...
*More publications can be found for each product on its corresponding product page