TRPM7 Antibodies

AND TRPM7 ELISA kits, TRPM7 Proteins

Many biological assays use antibodies to detect TRPM7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPM7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPM7 antibodies...

We validate the specificity of these antibodies to TRPM7 by testing them on tissues known to express TRPM7 positively and negatively. Browse below to find the TRPM7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for TRPM7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the TRPM7 Western Blot Guide

TRPM7 Infographic by Boster Bio

All TRPM7 Products

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Specificity

Applications

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Anti-TRPM7 Antibody Picoband®

Western blot analysis of TRPM7 using anti-TRPM7 antibody (A00789-1)

IF analysis of TRPM7 using anti-TRPM7 antibody (A00789-1)

Flow Cytometry analysis of THP-1 cells using anti-TRPM7 antibody (A00789-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00789-1
100 μg/vial

Anti-TRPM7 Monoclonal Antibody

2 Citations

Western blot analysis of TRPM7 expression in HeLa cell lysate

LBQ657 significantly extenuated TGF-β1 induced cardiac fibroblast activation in MEF

LBQ657 protected against fibrosis by blocking TRPM7 channel

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M00789
100 μl

TRPM7 Overview

Facts about Transient receptor potential cation channel subfamily M member 7.

TRPM7 3D structure. Source: alphafold

Transient receptor potential cation channel subfamily M member 7 (TRPM7)

Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death.

Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function.

Gene Information

Human
Gene Name:	TRPM7
Uniprot:	Q96QT4
Entrez:	54822

Family

Belongs to:

No superfamily

Alternative Names

CHAK; CHAK1FLJ25718; Channel-kinase 1; EC 2.7.11.1; Long transient receptor potential channel 7; LTRPC ion channel family member 7; LTrpC7; LTrpC-7; LTRPC7FLJ20117; transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential-phospholipase C-interacting kinase; TRP-PLIK

Molecular Weight

Mass (kDA):
212.697 kDA

Genomic Context


Human

Location:	15q21.2
Sequence:	15; NC_000015.10 (50557158..50686797, complement)

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Malignant Neoplasms
Ischemia
Neoplasms
Hypertensive Disease
Brain Ischemia
Magnesium Deficiency
Tissue Adhesions
Hypocalcemia
Cerebrovascular Accident
Adenocarcinoma
Diabetes Mellitus
Cardiovascular Diseases

Malignant Neoplasm Of Breast
Fibrosis
Basophilic Leukemia
Cerebral Ischemia
Inflammation
Leukemia
Brain Injuries

Pathways

Transport
Cell Death
Cell Proliferation
Cell Growth
Cell Adhesion
Cell Migration
Pathogenesis
Excretion
Localization
Rna Interference
Cell Cycle
Intestinal Absorption
Secretion

Neuroprotection
Immune Response
Membrane Depolarization
Cell Division
Cell Differentiation
Gene Silencing
Reverse Transcription

PTMs

Phosphorylation
Cleavage

Nitration
Nitrosylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPM7

References

PMID: 11385574 by Nadler M.J.S., et al. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability.

PMID: 14594813 by Ryazanova L.V., et al. Characterization of the protein kinase activity of TRPM7/ChaK1, a protein kinase fused to the transient receptor potential ion channel.