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Facts about Thioredoxin reductase 2, mitochondrial.
May play a role in redox-regulated cell signaling. .
Human | |
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Gene Name: | TXNRD2 |
Uniprot: | Q9NNW7 |
Entrez: | 10587 |
Belongs to: |
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class-I pyridine nucleotide-disulfide oxidoreductase family |
EC 1.8.1; EC 1.8.1.9; KIAA1652; Selenoprotein Z; SelZ; Thioredoxin Reductase 2; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR3; TR-beta; TRXR2; TRXR2thioredoxin reductase 2, mitochondrial; TXNRD2
Mass (kDA):
56.507 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (19875518..19941818, complement) |
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).
Mitochondrion.
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Gasdaska and colleagues discovered that the TXNRD2 gene may reduce oxidative stress in cells by inhibiting the opening of the mitochondrial permeability transition port. How does this protein accomplish this? What are its biological functions, then? This study reveals its intricate workings. Let's take a look at some of its functions.
Mutagenesis of a corresponding gene is one way to investigate TXNRD2's gene. Site-directed PCR mutation was performed using a pGEM–T-Easy–Txnrd2 template. To create an Ala-T mutation, we used the Ala codeon in Txnrd2. To make a G375R mutagenesis, we changed Gly to Arg.
PMID: 10455115 by Sun Q.-A., et al. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.
PMID: 9923614 by Gasdaska P.Y., et al. Cloning, sequencing and functional expression of a novel human thioredoxin reductase.