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- Table of Contents
Facts about Tripartite motif-containing protein 16.
Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. Consequently, protects the cell against oxidative stress-induced cell death as a result of endomembrane damage.
Human | |
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Gene Name: | TRIM16 |
Uniprot: | O95361 |
Entrez: | 10626 |
Belongs to: |
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TRIM/RBCC family |
DKFZp434O1826; EBBPtripartite motif-containing 16; Estrogen-responsive B box protein; tripartite motif containing 16; tripartite motif-containing protein 16
Mass (kDA):
63.955 kDA
Human | |
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Location: | 17p12 |
Sequence: | 17; NC_000017.11 (15627966..15684311, complement) |
Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
Cytoplasm.
If you are looking for a TRIM16 marker, you have come to the right spot. This Boster bio will provide information about Boster's history, the TRIM16Marker, and other markers. In addition, you'll learn how to use the TRIM16 Marker effectively. This Boster bio will help determine if this marker would be the right choice for you.
You are interested in Steve Boster’s history? You have come to the right place. You can access Steve Boster's public records to find all relevant information. This includes his current and past addresses as well his mobile phone and email addresses. There are also any known relatives. Filtering for age or by state will allow you to narrow your search down to a specific area. You can also search for Steve Boster's birth and death dates if you are interested in his background.
Steve Boster was a Joliet native, IL resident. He was a successful manager in retail sales for many years and an Army veteran. He was a Concordia Hall member in Staunton, Virginia. He also had two daughters, Natosha and Crystal. He was also survived his 6 Grandchildren and 4 Brothers Jack Boster and Sandra Blanton, as well as his sister Tammy. Steve had many nieces.
The tumor suppressor proteins TRIM16 and TRIM16 are genes. It acts as an inhibitor of cell growth, movement, and proliferation as well inducing apoptosis. However, the best uses of the TRIM16 gene are not yet clear. The next step in research will be to determine the role that TRIM16 plays in different types of cancer. In this article, we will discuss several potential uses of the TRIM16 gene in cancer.
TRIM16 has tumour-suppressor qualities, as it binds to key target proteins in the cytoplasmic and nucleus. It decreases nuclear E2F1 levels and cytoplasmic vimentin. These factors have an immediate effect on cell growth, migration, and survival. TRIM16 also exhibits ubiquitin ligase, which allows for cellular interaction with other proteins.
TRIM16 can also be used to treat neuroblastoma. The most common solid tumor in children, it accounts for 15% of all deaths from childhood cancer. TRIM16 belongs to the RING B family of proteins. It has been shown that it can influence neuroblastoma cell migration and proliferation both in vitro, and in vivo. There are currently no clinical trials using this gene to treat neuroblastoma.
TRIM16 protein expression correlates with the cell cycle. To stop cell proliferation, differentiation is possible only if it is stopped. Immunofluorescence was used to measure TRIM16 expression within neuroblastoma cells. The TRIM16 proteins were co-stained by DAPI which is a nuclear/DNA marker. It was found out that TRIM16 was primarily expressed within the cytoplasmic BE2C and SHEP neuroblastoma lines. The expression was lower in neuroblastoma line cell lines at G0, G1 phases, with the notable exception of the BE2C.
The caspase family includes the TRIM16 gene. This family is known for its role in programmed cell death and is a promising target for future therapies. Now, research is underway to discover how caspase-2 activates in cells. A biochemical approach reveals a novel mechanism for TRIM16-induced apoptosis. TRIM16 promotes caspase-2 activation within the MCF7 cell line for breast cancer.
The chromosome 17p11.2 hosts the TRIM16 gene. The protein encoded in this gene is part of the tripartite molecular motif protein family, also called the RBCC protein family. It has two B box-type zinc fingers domains and one SPRY domain. Its expression is highest among the testis, basal keratinocytes and fetus. Its excessive expression has been shown to increase histone-acetylation in retinoidresistant cancer cells. Thus, TRIM16 may be an ideal target for therapeutic drugs.
The TRIM16 antibodies is a marker that is highly specific for determining cellular response in biological samples. It is useful for many research applications, including immunohistochemistry, cell imaging, and gene therapy. The boster brand is made up of highly-affinity primary antibodies, which have been extensively validated in scientific circles over the past 25 year. Boster offers TRIM16 antibodies in a range dilutions which is not offered by many other companies.
PMID: 9817599 by Liu H.-L.C., et al. The novel estrogen-responsive B box protein (EBBP) gene is tamoxifen regulated in cells expressing an estrogen receptor DNA-binding domain mutant.
PMID: 11919186 by Beer H.-D., et al. The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation.