Uroplakin-1b Antibodies

AND UPK1B ELISA kits, Uroplakin-1b Proteins

Many biological assays use antibodies to detect Uroplakin-1b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Uroplakin-1b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Uroplakin-1b antibodies...

We validate the specificity of these antibodies to Uroplakin-1b by testing them on tissues known to express UPK1B positively and negatively. Browse below to find the UPK1B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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UPK1B Infographic by Boster Bio

All UPK1B Products

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Anti-Uroplakin-1b UPK1B Antibody

Western blot analysis of UPK1B in human kidney tissue lysate with UPK1B antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide

Immunohistochemistry of UPK1B in human bladder tissue with UPK1B antibody at 5 μg/mL

Immunofluorescence of UPK1B in human bladder muscle tissue with UPK1B antibody at 20 μg/mL

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$481
Cat # A10230
0.1 mg

Anti-Uroplakin Ib/UPIb Antibody Picoband®

Western blot analysis of Uroplakin Ib/UPIb using anti-Uroplakin Ib/UPIb antibody (A10230-1)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A10230-1
100 μg/vial

UPK1B Overview

Facts about Uroplakin-1b.

UPK1B 3D structure. Source: alphafold

Uroplakin-1b (UPK1B)

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an essential role in normal bladder epithelial physiology, maybe in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

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Gene Information

Human
Gene Name:	UPK1B
Uniprot:	O75841
Entrez:	7348

Family

Belongs to:

tetraspanin (TM4SF) family

Alternative Names

tetraspanin-20; TSPAN20; tspan-20; TSPAN20tetraspan; UP1b; UPIB; UPK1; UPK1B; Uroplakin 1B; Uroplakin Ib; uroplakin-1b

Molecular Weight

Mass (kDA):
29.643 kDA

Genomic Context


Human

Location:	3q13.32
Sequence:	3; NC_000003.12 (119173598..119205143)

Tissue Specificity

Bladder epithelium.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Carcinoma
Carcinoma, Transitional Cell
Bladder Neoplasm
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Urinary Bladder
Gastroesophageal Reflux Disease
Dental Plaque
Vesico-ureteral Reflux
Neoplasm Metastasis
Malignant Paraganglionic Neoplasm
Urinary Tract Infection

Metaplasia
Metastatic Malignant Neoplasm To The Lymph Node
Hereditary Diseases
Urologic Neoplasms
Hydronephrosis
Infective Disorder
Pathological Dilatation

Interacting Proteins

DAGLA

Pathways

Localization
Pathogenesis
Cell Proliferation
Glycosylation
Methylation
Reverse Transcription
Cell Adhesion
Egg Activation
Fertilization
Urothelial Cell Proliferation
Leukocyte Differentiation

Regeneration
Mismatch Repair
Cell Death
Cell Differentiation
Cell Growth
Wound Healing

PTMs

Methylation
Glycosylation
Phosphorylation

Biotinylation
Cleavage
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UPK1B

References

PMID: 9818021 by Yuasa T., et al. Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma.

PMID: 9935153 by Finch J.L., et al. Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue.