Uroplakin-1b Antibodies

Uroplakin-1b (UPK1B)

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an essential role in normal bladder epithelial physiology, maybe in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

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Gene Information

Human
Gene Name:	UPK1B
Uniprot:	O75841
Entrez:	7348

Family

Belongs to:
tetraspanin (TM4SF) family

Alternative Names

tetraspanin-20; TSPAN20; tspan-20; TSPAN20tetraspan; UP1b; UPIB; UPK1; UPK1B; Uroplakin 1B; Uroplakin Ib; uroplakin-1b

Molecular Weight

Mass (kDA):
29.643 kDA

Genomic Context

Human
Location:	3q13.32
Sequence:	3; NC_000003.12 (119173598..119205143)

Tissue Specificity

Bladder epithelium.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

• Carcinoma
• Carcinoma, Transitional Cell
• Bladder Neoplasm
• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Urinary Bladder
• Gastroesophageal Reflux Disease
• Dental Plaque
• Vesico-ureteral Reflux
• Neoplasm Metastasis
• Malignant Paraganglionic Neoplasm
• Urinary Tract Infection

• Metaplasia
• Metastatic Malignant Neoplasm To The Lymph Node
• Hereditary Diseases
• Urologic Neoplasms
• Hydronephrosis
• Infective Disorder
• Pathological Dilatation

Interacting Proteins

• DAGLA

Pathways

• Localization
• Pathogenesis
• Cell Proliferation
• Glycosylation
• Methylation
• Reverse Transcription
• Cell Adhesion
• Egg Activation
• Fertilization
• Urothelial Cell Proliferation
• Leukocyte Differentiation

• Regeneration
• Mismatch Repair
• Cell Death
• Cell Differentiation
• Cell Growth
• Wound Healing

PTMs

• Methylation
• Glycosylation
• Phosphorylation

• Biotinylation
• Cleavage
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/UPK1B

Boster Bio Anti-Uroplakin Ib/UPIb Antibody PicoBand

Are you thinking about purchasing the Boster Bio Anti-Uroplakin Ib/UPIb Antibody Pikoband(tm). Are you unsure about what this immunofluorescence antibody is? Find out how to make the most of this antibody. This guide can help you choose the appropriate antibody for your specific needs. Continue reading to learn more about Immunofluorescence.

Boster Bio Anti-Uroplakin Ib/UPIb Antibody Picoband(tm)

The Boster Bio Anti-Uroplakin-Ib/UPIb Antibody PicoBand(tm) reacts with Human, Mouse, and Rat. The product is kept at -20°C for a year. This product contains 5mg of BSA and a peptide sequence that includes the N-terminus human PDK4. These antibodies can also be used in studies involving immunogens that have a high affinity with cellular membranes.

Boster Bio Anti-Uroplakin Ib/UPIb Antibody

This antibody is made to detect the protein Uroplakin Ib (UPIb). It has been found in many non-urothelial tissues such as the ovary and stomach. This product also detects uroplakins in human ovary cells, which are enriched in keratin 8 (K8).

Uroplakin Ia, a receptor for type 1 Uropathogenic Escherichia Coli, is known as Uroplakin. This antibody recognizes uroplakin only when it is detected in biological samples. Similar results were achieved by using multiple antibodies with the antibody. In addition to detecting UPK1, this antibody also recognizes a protein called tetraspanin.

Boster Bio Anti-Uroplakin ib/UPIb Antibody uses the marker UPK1B in mice and human oocytes. It colocalizes with CD9 and tyrosine-phosphorylated UPIIIa. Moreover, it colocalizes with GM1 and fyn.

The uroplakin Ib/UPIb is an excellent choice for research on oocyte differentiation. The UPK1B antibody recognizes the amino acids 110 - 160 of human UPK1B. The antibody is provided in PBS containing 0.2% sodium azide. The antibody was raised against a synthetic protein that covers the central region in human UPK1B. The peptide that binds the antibody should be of a specific length.

Uroplakin Ib/UPIb antibodies are also effective in other cancer tests. To detect uroplakins, they use UPK1B markers. The protein can be found in cells at the cytoplasmic and pericellular edges. It is found within follicles but not in the cortex.

Mutations in UPIIIa may cause kidney failure. UPIIIa variants can lead to renal adysplasia. UPIIIa mutations can cause renal failure, urinary insufficiency, and uroplakin positive tumors. In rare cases, tumors may arise from a subset of UPIb positive cells. Uroplakin staining may help to diagnose the condition.

This Boster Bio Anti-Uroplakin-Ib/UPIb Antibody uses the phosphorylated UPK1B marker to detect uroplakins. This antibody binds with the UPK1B mark and also a -tubulin. It can also detect a-tubulin and acrosome markers.

The protein is highly expressed in mammalian urothelia, and is called urothelium-specific. However, it has been found in other tissues as well, including the bladder of zebrafish, fat cells, and oocytes. It may also play other roles in non-urothelial cells.

Uroplakin Ib/UPIb is a two-dimensional protein that plays an ancestral role in fertilization. Nonurothelial mouse cell lines also contain mammal uroplakin genes. Their two-dimensional crystallins mediate signal transduction and regulate membrane stability. They also act to protect and protect against permeability.

Moreover, the anti-UPIIIa/UPIIIa-like protein may play an important role in mouse fertilization. Fertile mice that are uroplakin II or IIIa knockout are the ones that are uroplakin. It is possible for nonmammals to not have the uroplakin plaques because the gene responsible is highly conserved among vertebrates.

Immunofluorescence

The UPK1B gene encodes a protein called uroplakin-1b (UPK1B). It is a member of the transmembrane superfamily, also known as the tetraspanin family, which is expressed in a wide variety of cell types. It regulates cell growth and signal transduction. It is located in the asymmetric unit membrane and forms complexes with other members of this superfamily.

An epitope can be identified by the UPK1B-marker. An epitope is any molecule or portion that can be recognized as an antibody. It can bind an antigen and instigate the immune system into producing antibodies. Multiple epitopes can be recognized by a single antibody. This indicates that the epitope's specificity is high. This is a feature of the T2DBMARKERS molecule, which is a subtype of the UPK1B.

The present invention identifies a biomarker which is associated with a higher risk of developing diabetes. This invention relates to the use of these markers for the diagnosis of and treatment of diabetes. These biological markers are new targets and therapeutics to treat diabetes. These biomarkers could prove to be useful in clinical applications. It is important to remember that the UPK1B marker can have many benefits.