Ubiquitin carboxyl-terminal hydrolase 13 (USP13)

Deubiquitinase which mediates deubiquitination of target proteins like BECN1, MITF, SKP2 and USP10 and is involved in various processes like autophagy and endoplasmic reticulum- associated degradation (ERAD). Part of a regulatory loop which controls autophagy and p53/TP53 amounts: mediates deubiquitination of BECN1, a crucial regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes.

Additionally deubiquitinates USP10, an essential regulator of p53/TP53 stability. Subsequently, PIK3C3/VPS34- containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels through USP10 and USP13.