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USP16 Antibodies
AND USP16 ELISA kits, USP16 Proteins
Many biological assays use antibodies to detect USP16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with USP16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop USP16 antibodies...
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USP16 Infographic by Boster Bio
All USP16 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05795
100 μg/vial
Cat # A05795
100 μg/vial
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A05795-2
100 μg/vial
Cat # A05795-2
100 μg/vial
USP16 Overview
Facts about Ubiquitin carboxyl-terminal hydrolase 16.
Ubiquitin carboxyl-terminal hydrolase 16 (USP16)
Specifically deubiquitinates'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis.
In resting B- and T- lymphocytes, phosphorylation by AURKB contributes to enhance its activity, thereby keeping transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination.
Gene Information
| Human | |
|---|---|
| Gene Name: | USP16 |
| Uniprot: | Q9Y5T5 |
| Entrez: | 10600 |
Family
| Belongs to: |
|---|
| peptidase C19 family |
Alternative Names
Deubiquitinating enzyme 16; EC 3.1.2.15; EC 3.4.19.12; human ubiquitin processing protease, EC 3.1.2.1510ubiquitin specific protease 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific peptidase 16; ubiquitin thioesterase 16; Ubiquitin thiolesterase 16; Ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; Ubiquitin-specific-processing protease 16; UBP-M
Molecular Weight
Mass (kDA):
93.57 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q21.3 |
| Sequence: | 21; NC_000021.9 (29024617..29054488) |
Tissue Specificity
Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus.
Diseases
- Trisomy 8
- Myelomonocytic Leukemia
- Carcinoma
- Carcinogenesis
- Nonalcoholic Steatohepatitis
- Insulin Resistance
- Malignant Neoplasms
- Neoplasms
- Leukemia, Myelomonocytic, Chronic
- Hematological Disease
- Cytogenetic Abnormality
- Dysmyelopoietic Syndromes
- Fatty Liver
Pathways
- Mitosis
- Cell Cycle
- Cell Growth
- Transport
- Histone Ubiquitination
- Regulation Of Cell Cycle
- Gene Silencing
- Proteolysis
- Regulation Of Gene Expression
PTMs
- Phosphorylation
- Ubiquitination
- Carboxylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USP16
bosterbio.com/bosterbio-gene-info-cards/USP16
References
PMID: 10077596 by Cai S.-Y., et al. A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division.
PMID: 11753566 by Mimnaugh E.G., et al. Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli.