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- Table of Contents
Villin-1 Antibodies
AND VIL1 ELISA kits, Villin-1 Proteins
Many biological assays use antibodies to detect Villin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Villin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Villin-1 antibodies...
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VIL1 Infographic by Boster Bio
All VIL1 Products
Product
Figures
Specificity
Applications
Price
Anti-Villin/VIL1 Antibody Picoband®
5 Citations 3 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$370
Cat # PB9457
100 μg/vial
Cat # PB9457
100 μg/vial
VIL1 Overview
Facts about Villin-1.
Villin-1 (VIL1)
Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2.
Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying actions. Binding to PIP2 inhibits actin-capping and -severing actions but enhances actin-bundling activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | VIL1 |
| Uniprot: | P09327 |
| Entrez: | 7429 |
Family
| Belongs to: |
|---|
| villin/gelsolin family |
Alternative Names
D2S1471; VIL; villin 1; villin-1
Molecular Weight
Mass (kDA):
92.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (218419123..218453295) |
Tissue Specificity
Specifically expressed in epithelial cells. Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells. Expressed in canalicular microvilli of hepatocytes (at protein level).
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip. Cell projection, filopodium. Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphat
Diseases
- Neoplasms
- Malignant Neoplasms
- Adenocarcinoma
- Carcinoma
- Uterine Cervical Neoplasm
- Endometrial Polyp
- Fibrolamellar Carcinoma
- Colorectal Cancer
- Endometrial Adenocarcinoma
- Leishmaniasis, Visceral
- Malignant Tumor Of Cervix
- Cervical Adenocarcinoma
- Leishmaniasis
Interacting Proteins
- PLCG1
Pathways
- Localization
PTMs
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VIL1
bosterbio.com/bosterbio-gene-info-cards/VIL1
References
PMID: 2846586 by Arpin M., et al. Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity.
PMID: 3453110 by Pringault E., et al. A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture.
2 Publications of Boster Villin-1 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fmicb.2020.622354, Prevention and Alleviation of Dextran Sulfate Sodium Salt-Induced Inflammatory B...
- PubMed ID: 10.1080/00365520902998661, Acid and bile salt up-regulate BMP4 expression in human esophageal epithelium ce...
*More publications can be found for each product on its corresponding product page