Product Info Summary
SKU: | M32338 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human |
Host: | Mouse |
Application: | Flow Cytometry, IP, WB |
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Product info
Product Name
Anti-ABRA1 Purified ABRAXAS1 Monoclonal Antibody
SKU/Catalog Number
M32338
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ABRA1 Purified ABRAXAS1 Monoclonal Antibody (Catalog# M32338). Tested in Flow Cytometry, IP, WB application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-ABRA1 Purified ABRAXAS1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M32338)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
ABRA1-01
Isotype
Mouse IgG2a kappa
Immunogen
Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag. The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M32338 is reactive to Abraxas1 in Human
Applications
M32338 is guaranteed for Flow Cytometry, IP, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
46.039kDa
Background of Abraxas
ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-2 μg/ml. Intracellular staining.
Western blotting: Reducing conditions.
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-ABRA1 Purified ABRAXAS1 Monoclonal Antibody M32338
Western blotting detection of ABRA1-EGFP fusion protein in lysate of transfected HEK293 cells.Lane A: Immunostaining with anti-ABRA1 (clone ABRA1-01)
Lane B: Immunostaining with anti-EGFP (polyclonal)
Lane C: Immunostaining with anti-alpha tubulin (clone TU-01)
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For Abraxas1 (Source: Uniprot.org, NCBI)
Gene Name
Abraxas1
Full Name
BRCA1-A complex subunit Abraxas 1
Weight
46.039kDa
Superfamily
FAM175 family
Alternative Names
BRCA1-A complex subunit Abraxas; ABRA1; CCDC98; family with sequence similarity 175, member A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Abraxas1, check out the Abraxas1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Abraxas1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ABRA1 Purified ABRAXAS1 Monoclonal Antibody (M32338)
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No publications found for M32338
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