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AP-2 complex subunit beta Antibodies
AND AP2B1 ELISA kits, AP-2 complex subunit beta Proteins
Many biological assays use antibodies to detect AP-2 complex subunit beta, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AP-2 complex subunit beta in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AP-2 complex subunit beta antibodies...
Designing a Western blot for AP-2 complex subunit beta? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the AP2B1 Western Blot GuideAP2B1 Infographic by Boster Bio
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AP2B1 Overview
Facts about AP-2 complex subunit beta.
AP-2 complex subunit beta (AP2B1)
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways.
Adaptor protein complexes are vesicle coat components and seem to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are integrated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome.
Gene Information
| Human | |
|---|---|
| Gene Name: | AP2B1 |
| Uniprot: | P63010 |
| Entrez: | 163 |
Family
| Belongs to: |
|---|
| adaptor complexes large subunit family |
Alternative Names
Adapter-related protein complex 2 beta subunit; Adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; ADTB2adaptin, beta 2 (beta); AP105B; AP2-BETA; beta-2-adaptin; beta-adaptin; CLAPB1AP-2 complex subunit beta; Clathrin assembly protein complex 2 beta large chain; clathrin-associated/assembly/adaptor protein, large, beta 1; DKFZp781K0743; Plasma membrane adaptor HA2/AP2 adaptin beta subunit
Molecular Weight
Mass (kDA):
104.553 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q12 |
| Sequence: | 17; NC_000017.11 (35587265..35726413) |
Subcellular Localizations
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
Diseases
- Malignant Neoplasms
- Stomach Neoplasms
- Malignant Neoplasm Of Stomach
- Ear Inflammation
- Malignant Neoplasm Of Ovary
- Otitis Media
Interacting Proteins
- AFF4
- AP1M2
- AP2M1
- Ap2m1
- KPNA2
- LDLRAP1
- MEA1
- MLH1
- Necap1
- SLC25A6
Pathways
- Cell Junction Assembly
- Cell Proliferation
- Integrin-mediated Signaling Pathway
- Epithelial Cell Proliferation
- Regulation Of Epithelial Cell Proliferation
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AP2B1
bosterbio.com/bosterbio-gene-info-cards/AP2B1
References
PMID: 1969413 by Ponnambalam S., et al. Conservation and diversity in families of coated vesicle adaptins.
PMID: 15897975 by Zhang X.D., et al. Expression of a novel beta adaptin subunit mRNA splice variant in human testes.