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Product Info Summary
| SKU: | A03607-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-IL-37 Antibody
SKU/Catalog Number
A03607-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-37 Antibody (Catalog # A03607-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
IL-37 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-IL-37 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03607-1)
Host
Rabbit
Contents
IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-37 antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37. The immunogen is located within amino acids 30 - 80 of IL-37 .
Cross-reactivity
IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.
Reactive Species
A03607-1 is reactive to IL37 in Human
Observed Molecular Weight
68 kDa
Calculated molecular weight
24.1 kDa
Background of IL37
Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1). It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1). IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03607-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-37 antibody can be used for detection of IL-37 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 μg/ml in (A) the presence and (B) the absence of blocking peptide.
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Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 μg/mL.
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Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 μg/mL.
Specific Publications For Anti-IL-37 Antibody (A03607-1)
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