Nuclear receptor ROR-gamma (RORC)

Nuclear receptor that binds DNA as a monomer to ROR response components (RORE) containing one core motif half-site 5'-AGGTCA-3' preceded by a brief A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm in addition to lipid, steroid, xenobiotics and sugar metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100).

Considered to possess intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts.