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- Table of Contents
ROCK2 Antibodies
AND ROCK2 ELISA kits, ROCK2 Proteins
Many biological assays use antibodies to detect ROCK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ROCK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ROCK2 antibodies...
Designing a Western blot for ROCK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ROCK2 Western Blot GuideROCK2 Infographic by Boster Bio
All ROCK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01023-1
100 μg/vial
Cat # A01023-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01023-2
100 µg/vial
Cat # A01023-2
100 µg/vial
ROCK2 Overview
Facts about Rho-associated protein kinase 2.
Rho-associated protein kinase 2 (ROCK2)
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility through phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM.
Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | ROCK2 |
| Uniprot: | O75116 |
| Entrez: | 9475 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
coiled-coil-containing protein kinase 2; EC 2.7.11; EC 2.7.11.1; KIAA0619; p164 ROCK-2; Rho kinase 2; rho-associated protein kinase 2; Rho-associated, coiled-coil containing protein kinase 2; ROCK2; ROCK-II; ROKalpha
Molecular Weight
Mass (kDA):
160.9 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p25.1 |
| Sequence: | 2; NC_000002.12 (11179759..11345437, complement) |
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic, and associated with actin microfilaments and the plasma membrane.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Hypertensive Disease
- Neoplasms
- Cardiovascular Diseases
- Cell Invasion
- Inflammation
- Carcinoma
- Neoplasm Metastasis
- Pathologic Vasoconstriction
- Neoplasm Invasiveness
- Pulmonary Hypertension
- Atherosclerosis
Interacting Proteins
- JAK2
- STAT3
Pathways
- Cell Migration
- Pathogenesis
- Cell Motility
- Cell Adhesion
- Vasoconstriction
- Cell Proliferation
- Cell Cycle
- Cytokinesis
- Sensitization
- Angiogenesis
- Muscle Contraction
- Smooth Muscle Contraction
- Cell Death
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
Research Areas
- Breast Cancer
- Cancer
- Protein Kinase
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ROCK2
bosterbio.com/bosterbio-gene-info-cards/ROCK2
References
PMID: 9933571 by Takahashi N., et al. Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.
PMID: 10579722 by Kawano Y., et al. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.
7 Publications of Boster ROCK2 Antibodies & ELISA Kits
- PubMed ID: 10.4103/1673-5374.165512, The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in...
- PubMed ID: 10.1002/jcp.21923, ROCK pathway participates in the processes that 15‐hydroxyeicosatetraenoic aci...
- PubMed ID: 32990282, Han F,Xu H,Shen JX,Pan C,Yu ZH,Chen JJ,Zhu XL,Cai YF,Lu YP.RhoA/Rock2/Limk1/cofi...
- PubMed ID: 27284349, ROCK2 mediates the proliferation of pulmonary arterial endothelial cells induced...
- PubMed ID: 20493836, 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cell...
- PubMed ID: 26604905, The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in...
- PubMed ID: 23181278, Wang Hm, Wang Y, Liu M, Bai Y, Zhang Xh, Sun Yx, Wang Hl. Can J Physiol Pharmaco...
*More publications can be found for each product on its corresponding product page