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- Table of Contents
Facts about Long-chain-fatty-acid--CoA ligase 4.
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Human | |
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Gene Name: | ACSL4 |
Uniprot: | O60488 |
Entrez: | 2182 |
Belongs to: |
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ATP-dependent AMP-binding enzyme family |
ACS4mental retardation, X-linked 68; acyl-CoA synthetase 4; acyl-CoA synthetase long-chain family member 4; EC 6.2.1.3; FACL4long-chain 4; LACS 4; LACS4MRX68; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 4; mental retardation, X-linked 63; MRX63
Mass (kDA):
79.188 kDA
Human | |
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Location: | Xq23 |
Sequence: | X; NC_000023.11 (109641335..109733392, complement) |
Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.
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Researchers have discovered that the ACSL4 marker may serve as a useful prognostic biomarker for pan-cancer. ACSL4 promotes cell growth and activation of the cell cycle, while inhibiting apoptosis. Researchers hope that by targeting this marker, they can more accurately predict how a patient will respond to chemotherapy or radiation. But determining its precise role in predicting cancer risk is challenging.
Previous studies have suggested that ACSL4 is involved in the execution of ferroptosis in human malignant tumors. While its role in ferroptosis varies between different types of cancer, ACSL4 is a component of ferroptosis in HCC cells. Despite these results, the role of ACSL4 in HCC has not been thoroughly investigated. The underlying mechanism of ACSL4 regulation is still not completely understood.
Further work has confirmed that ACSL4 is a key player in ferroptosis. Targeting ACSL4 may limit the death of skeletal muscle cells in patients after EHS. Moreover, targeting ACSL4 may also prevent RM. While EHS is not a cure for all forms of cancer, it can significantly reduce the risk of developing RM. There is little evidence that the ACSL4 gene is responsible for this complication.
The ACSL4 marker has been a promising new prognostic biomarker for pan-cancer. In addition, ACSL4 has been associated with immune infiltration in tumor microenvironments. Therefore, the markers ACSL3 and ACSL4 might play a crucial role in fatty acid metabolism compartmentalisation. However, the exact mechanism of ACSL4 action remains unknown. However, ACSL3 is essential for its function in the cell's cytoplasm, and its occurrence in the liver suggests that ACSL4 is involved in liver apoptosis.
PMID: 9598324 by Cao Y., et al. Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4).
PMID: 9480748 by Piccini M., et al. FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation.