ACSL4 Antibodies

Long-chain-fatty-acid--CoA ligase 4 (ACSL4)

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation through beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

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Gene Information

Human
Gene Name:	ACSL4
Uniprot:	O60488
Entrez:	2182

Family

Belongs to:
ATP-dependent AMP-binding enzyme family

Alternative Names

ACS4mental retardation, X-linked 68; acyl-CoA synthetase 4; acyl-CoA synthetase long-chain family member 4; EC 6.2.1.3; FACL4long-chain 4; LACS 4; LACS4MRX68; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 4; mental retardation, X-linked 63; MRX63

Molecular Weight

Mass (kDA):
79.188 kDA

Genomic Context

Human
Location:	Xq23
Sequence:	X; NC_000023.11 (109641335..109733392, complement)

Subcellular Localizations

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Neoplasms
• Fatty Liver
• Diabetes Mellitus
• Cell Transformation, Neoplastic
• Carcinoma
• Mammary Neoplasms
• Liver Carcinoma
• Steatosis
• Muscle Hypotonia
• Diabetes Mellitus, Non-insulin-dependent

• Insulin Resistance
• Nonalcoholic Fatty Liver Disease
• Insulin Sensitivity
• Autoimmunity
• Malignant Tumor Of Colon
• Neuromuscular Diseases

Pathways

• Transport
• Pathogenesis
• Cell Proliferation
• Fatty Acid Transport
• Cell Adhesion
• Gene Silencing
• Endocytosis
• Membrane Fusion
• Energy Homeostasis
• Methylation
• Dna Replication

• Reverse Transcription
• Lipid Homeostasis
• Lipid Storage
• Segmentation
• Glycolysis
• Secretion

PTMs

• Acetylation
• Methylation

• Oxidation
• Acylation

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACSL4

Steven Boster Bio - Best Uses Of The ACSL4 Marker

If you are interested in Steven Boster's biography, you've come to the right place. Learn about His work, publications, and interests. And you'll discover why He is a great choice for ACSL4 marker kits. In this bio, you'll learn about the ACSL4 marker, and its benefits. Also, find out what He likes to do outside of ACSL4 markers.

His work

Researchers have discovered that the ACSL4 marker may serve as a useful prognostic biomarker for pan-cancer. ACSL4 promotes cell growth and activation of the cell cycle, while inhibiting apoptosis. Researchers hope that by targeting this marker, they can more accurately predict how a patient will respond to chemotherapy or radiation. But determining its precise role in predicting cancer risk is challenging.

Previous studies have suggested that ACSL4 is involved in the execution of ferroptosis in human malignant tumors. While its role in ferroptosis varies between different types of cancer, ACSL4 is a component of ferroptosis in HCC cells. Despite these results, the role of ACSL4 in HCC has not been thoroughly investigated. The underlying mechanism of ACSL4 regulation is still not completely understood.

Further work has confirmed that ACSL4 is a key player in ferroptosis. Targeting ACSL4 may limit the death of skeletal muscle cells in patients after EHS. Moreover, targeting ACSL4 may also prevent RM. While EHS is not a cure for all forms of cancer, it can significantly reduce the risk of developing RM. There is little evidence that the ACSL4 gene is responsible for this complication.

His publications

The ACSL4 marker has been a promising new prognostic biomarker for pan-cancer. In addition, ACSL4 has been associated with immune infiltration in tumor microenvironments. Therefore, the markers ACSL3 and ACSL4 might play a crucial role in fatty acid metabolism compartmentalisation. However, the exact mechanism of ACSL4 action remains unknown. However, ACSL3 is essential for its function in the cell's cytoplasm, and its occurrence in the liver suggests that ACSL4 is involved in liver apoptosis.