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- Table of Contents
1 Citations 1 Q&As
Facts about Alpha-actinin-3.
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Human | |
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Gene Name: | ACTN3 |
Uniprot: | Q08043 |
Entrez: | 89 |
Belongs to: |
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alpha-actinin family |
actinin, alpha 3; Alpha-actinin skeletal muscle isoform 3; alpha-actinin skeletal muscle; alpha-actinin-3; F-actin cross-linking protein; MGC117002; MGC117005
Mass (kDA):
103.241 kDA
Human | |
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Location: | 11q13.2 |
Sequence: | 11; NC_000011.10 (66546395..66563334) |
Expressed only in a subset of type 2 skeletal muscle fibers.
In this article, we will discuss the best uses of the ACTN3 genotype and the best products available for it. As a result, you will have a much better understanding of this marker and its potential uses. We will also cover some of the best Boster Bio products available for this marker. Continue reading to learn more! Here are some of the best products available for the ACTN3 genotype:
ACTN3, or a-actinin-3, is a structural component of the Z-membrane. It forms crosslinks between thin actin filaments. Fast muscle fibres, like those in sprint athletes, have high expression levels of ACTN3. However, many people do not have the full complement of this protein due to a common genetic variation. In these individuals, the X allele contains a sequence change that prevents the production of functional a-actinin-3.
ANOVA was performed to examine the relationship between ACTN3 genotype and testosterone levels. To determine the effect of each genotype on testosterone levels, we used the squared correlation coefficient R2. A significant correlation was identified by using Spearman's correlation with ACTN3 genotype and testosterone levels. Results were coded as means (SD) and were considered statistically significant at P = 0.05. For the majority of individuals, testosterone levels remained unaffected.
ACTN3 is important in the regulation of muscle differentiation and hypertrophy. It interacts with the signalling protein calcineurin. Inhibition of calcineurin increases the production of testosterone. Therefore, the ACTN3 XX genotype predicts deficiency in a-Actinin-3. Despite the potential for deficiency, the ACTN3 XX genotype has not yet been proven to affect serum testosterone levels in athletes. A study conducted in Russia included 209 elite athletes. Resting testosterone was measured using enzyme immunoassay.
Several studies have examined the relationship between the ACTN3 gene and power-athletes. However, a study by Yang et al. found no correlation between ACTN3 polymorphism and power. This finding raises questions regarding the role of ACTN3 in muscle injury risk. As more studies are conducted, the potential for ACTN3 to be used as a performance enhancer will be better understood.
The ACTN3 gene is an important regulator of muscle function in the elderly, and its polymorphism may be linked to the development of sarcopenia, bone mineral density loss, and metabolic disorders in elderly individuals. The findings suggest that genetic modifier effects of ACTN3 are not limited to DMD alone, and are likely to apply to a broad cross-section of muscle pathologies.
Loss of independent ambulation (LoA) is a condition in which a person needs a wheelchair to get around and cannot walk for at least 10 m without assistance. The LoA was assessed in a time-to-event statistical framework using age and LoA as time variables. This allows researchers to assess the role of ACTN3 in the development of LoA.
The ACTN3 gene is an important factor in the development of the DMD phenotype. Its phenotypic effects may be improved by identifying the genotype of individuals with DMD. The gene is a candidate for use in clinical trials for DMD. But its uses in this area are limited. Currently, research is focused on analyzing the role of ACTN3 in the development of muscle strength in DMD.
Actn3 affects five genes, including Tmem100 and Cbx8, which are involved in signal transduction pathways. Actn3 may also affect Fbxo32 and Trim63, two protein synthesis markers. And Actn3 has been linked to muscle wasting in Parkinson's disease. If you're interested in using Actn3 in clinical trials, contact your local research center. You can find more information about its uses in a clinical trial by reading the following article.
The ACTN3 marker has been linked to several health outcomes, including exercise performance and adaptation. However, few studies have explored the role of individual SNPs or the combined effect of SNPs on exercise performance. A recent study, published in Boster Bio, found that the ACTN3 polymorphism affects post-exercise adaptive response. Read on to learn more about this marker and its best uses.
The ACTN3 R577X polymorphism has been linked with exercise-induced muscle damage. Moreover, increased muscle damage will probably reduce the rate of muscle recovery. Therefore, it is important to identify how ACTN3 R577X influences muscle recovery and how it is influenced by other genetic variants. Eight studies have investigated the association between X allele and post-exercise muscle damage in humans.
Increasing slow-twitch muscle fiber in humans may enhance heat production and use less energy. This may be advantageous for infants and adults who live in cold climates. Additionally, the ACTN3 R577X polymorphism increases endurance and shifts muscle metabolism to more efficient aerobic pathways. It is important to note that this gene is not widely distributed, and it may be difficult to detect in healthy individuals.
PMID: 1339456 by Beggs A.H., et al. Cloning and characterization of two human skeletal muscle alpha- actinin genes located on chromosomes 1 and 11.
PMID: 11440986 by Mills M., et al. Differential expression of the actin-binding proteins, alpha-actinin- 2 and -3, in different species: implications for the evolution of functional redundancy.
*More publications can be found for each product on its corresponding product page