Activin receptor type-1 Antibodies

AND ACVR1 ELISA kits, Activin receptor type-1 Proteins

Many biological assays use antibodies to detect Activin receptor type-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Activin receptor type-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Activin receptor type-1 antibodies...

We validate the specificity of these antibodies to Activin receptor type-1 by testing them on tissues known to express ACVR1 positively and negatively. Browse below to find the ACVR1 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ACVR1 Infographic by Boster Bio

All ACVR1 Products

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Specificity

Applications

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Anti-Activin receptor type-1 ACVR1 Antibody

Western blot analysis of ACVR1 in A549 cell lysate with ACVR1 antibody at (A) 1 and (B) 2 μg/mL

Human, Mouse

ELISA, WB

$481
Cat # A00798
0.1 mg

Anti-ACVR1C Antibody

Western blot analysis of ACVR1C in human placenta tissue lysate with ACVR1C antibody at (A) 1 and (B) 2 μg/mL

Human, Mouse, Rat

ELISA, WB

$481
Cat # A00798-1
0.1 mg

Activin Receptor Type IA (ACVR1) (NM_001105) Human Recombinant Protein

Coomassie blue staining of purified ACVR1 protein

$1062
Cat # PROTQ04771
20 µg

Anti-Activin Receptor Type IA (ACVR1) Antibody (N-term)

Western blot analysis of lysates from A549,HepG2 cell line and rat testis tissue (from left to right),using ACVR1 Antibody (N-term)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining

Human, Rat

IHC-P, WB

$299
Cat # A00798-3
80 µl

Anti-Activin Receptor Type IA (ACVR1) Antibody (Center R147)

Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (R147)

ACVR1 Antibody (R147) western blot analysis in U937 cell line lysates (35ug/lane)

Western blot analysis of lysate from HepG2 cell line, using ACVR1 Antibody (R147)

Human

IHC-P, WB

$299
Cat # A00798-2
80 µl

Anti-ACVR1 Rabbit Monoclonal Antibody

1 Citations

Western blot analysis of ACVR1 using anti-ACVR1 antibody (M00798)

Human, Mouse, Rat

IP, WB

$370
Cat # M00798
100 μl/vial

Activin Receptor Type IA (ACVR1) (NM_001105) Human Over-expression Lysate

Activin Receptor Type IA (ACVR1) Human Over-expression Lysates NM_001105

Human

$628
Cat # LS000090
20 µg, 100 µg

Anti-ACVR1 / ALK-2 Reference Antibody (DS-6016a)

The purity of Anti-ACVR1/ALK-2 Reference Antibody (DS-6016a)is more than 95%

Cynomolgus monkey, Human

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M00798-1
100 μg

ACVR1 Overview

Facts about Activin receptor type-1.

ACVR1 3D structure. Source: alphafold

Activin receptor type-1 (ACVR1)

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.

Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity).

Gene Information

Human
Gene Name:	ACVR1
Uniprot:	Q04771
Entrez:	90

Family

Belongs to:

protein kinase superfamily

Alternative Names

activin A receptor, type I; Activin RIA; ActivinRIA; ACTRI; ACVR1; ACVR1A; ACVRLK2; ALK2; ALK-2; FOP; SKR1; TSRI

Molecular Weight

Mass (kDA):
57.153 kDA

Genomic Context


Human

Location:	2q24.1
Sequence:	2; NC_000002.12 (157736446..157876330, complement)

Tissue Specificity

Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Fibrodysplasia Ossificans Progressiva
Myositis Ossificans
Heterotopic Ossification
Hereditary Diseases
Malignant Neoplasms
Neoplasms
Congenital Abnormality
Inflammation
Pituitary Diseases
Congenital Disorders
Malignant Neoplasm Of Breast
Tumor Angiogenesis

Cell Transformation, Neoplastic
Adenocarcinoma
Bone Diseases
Infarction
De Novo Mutation
Severe Combined Immunodeficiency
Mammary Neoplasms

Pathways

Ossification
Cell Proliferation
Pathogenesis
Bmp Signaling Pathway
Cell Cycle
Secretion
Cell Differentiation
Angiogenesis
Osteoblast Differentiation
Endochondral Ossification
Cell Growth
Cell Migration
Gastrulation

Cell Death
Oncogenesis
Regeneration
S Phase
Proteolysis
Localization
Methylation

PTMs

Phosphorylation
Methylation

Demethylation
Glycosylation

Myristoylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ACVR1

References

PMID: 8389764 by Matsuzaki K., et al. A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.

PMID: 8397373 by ten Dijke P., et al. Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.