This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
ADAM12 Antibodies
AND ADAM12 ELISA kits, ADAM12 Proteins
Many biological assays use antibodies to detect ADAM12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAM12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAM12 antibodies...
Designing a Western blot for ADAM12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ADAM12 Western Blot GuideADAM12 Infographic by Boster Bio
All ADAM12 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A02264-2
100 μg/vial
Cat # A02264-2
100 μg/vial
Human
ELISA
$499
Cat # FEK0934
96 wells/kit, with removable strips.
Cat # FEK0934
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # EK0934
96 wells/kit, with removable strips.
Cat # EK0934
96 wells/kit, with removable strips.
ADAM12 Overview
Facts about Disintegrin and metalloproteinase domain-containing protein 12.
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)
Involved in skeletal muscle regeneration, especially at the beginning of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).
. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ADAM12 |
| Uniprot: | O43184 |
| Entrez: | 8038 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM 12; ADAM metallopeptidase domain 12; ADAM12; disintegrin and metalloproteinase domain-containing protein 12; EC 3.4.24; EC 3.4.24.58; MCMP; MCMPMltna; Meltrin alpha; meltrin-alpha; MLTNA; MLTNEC 3.4.24.-
Molecular Weight
Mass (kDA):
99.542 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q26.2 |
| Sequence: | 10; NC_000010.11 (126012391..126388477, complement) |
Tissue Specificity
Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.
Subcellular Localizations
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Down Syndrome
- Carcinoma
- Tumor Progression
- Pre-eclampsia
- Mammary Neoplasms
- Degenerative Polyarthritis
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Hypertrophy
Interacting Proteins
- CYSRT1
- FSTL3
- KRTAP5-6
- KRTAP9-2
- KRTAP9-8
Pathways
- Cell Adhesion
- Cell Proliferation
- Regeneration
- Pathogenesis
- Localization
- Myoblast Fusion
- Cell Migration
- Cell Differentiation
- Myoblast Differentiation
- Proteolysis
- Cell Growth
- Rna Interference
- Cellular Localization
PTMs
- Cleavage
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAM12
bosterbio.com/bosterbio-gene-info-cards/ADAM12
References
PMID: 9417060 by Gilpin B.J., et al. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
PMID: 9642263 by Loechel F., et al. Human ADAM 12 (meltrin alpha) is an active metalloprotease.