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Facts about Type-2 angiotensin II receptor.
Receptor for angiotensin II.
Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation..
Human | |
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Gene Name: | AGTR2 |
Uniprot: | P50052 |
Entrez: | 186 |
Belongs to: |
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G-protein coupled receptor 1 family |
AGTR2; AGTR-2; Angiostensin Receptor; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; angiotensin receptor 2; AT2; AT2ATGR2; AT2R; MRX88; MRX88type-2 angiotensin II receptor
Mass (kDA):
41.184 kDA
Human | |
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Location: | Xq23 |
Sequence: | X; NC_000023.11 (116170744..116174974) |
In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine.
Cell membrane; Multi-pass membrane protein.
This article will help you to understand the AGTR2 Marker and the different uses for this gene. It will also provide Biological applications for the AGTR2 Marker. There are details on the history of this gene, its applications, and some Gene infographics. Additionally, you will be able to learn about Steven Boster's life story. So, read on to find out more.
The human gene AGTR2 regulates the activity of a number of enzymes involved in steroid hormone metabolism. The gene has two coding exons, as well as a 3'-flanking zone that has an ATT trinucleotide repeat. The DNA is 2190 bp long , and is predicted to melt at 60 degrees Celsius. AGTR2's coding region is located 2190bp from the stop codon.
This gene is responsible to secrete angiotensin II which is a powerful vasopressor hormone. It also functions as a major regulator of aldosterone secretion and regulates blood pressure as well as the volume of the cardiovascular system. This hormone plays a crucial role in the growth of neurites and is involved in the growth and functioning of the kidney and the urinary tract. It also inhibits cell proliferation and regulates vasoconstriction.
The gene is located on chromosome X , and performs multiple functions. It has a low MAF which makes it difficult for its detection in association studies. The evidence suggests that it could be important for AT2R research. The gene is responsible for the production of a variety of the body's blood cell kinds. Further research is required to determine if this gene is involved in the production of hemoglobin.
The genetic variant rs11091046 encoding the AGTR2 gene has been found to be linked to power characteristics in a variety of populations. For example, Mustafina et al. studied the frequency of the AGTR2 A allele in female power athletes from Poland and Russia. The A allele was significantly more prevalent in female power athletes than the C. In male strength athletes the reverse was true for the AGTR2C allele.
The protein is thought to function as an angiotensin II receptor within cells. It is responsible for modulating the inflammation response, as well as positive regulation of blood vessel size. Human orthologs of the AGTR2 gene have been linked to end-stage renal failure, IgA glomerulonephritis, and intellectual disabilities. AGTR2 is expressed in the blood vasculature, post-vent region, posterior lateral plate mesoderm, trunk, and vascular cord.
Furthermore, the expression of AGTR2 on lung fibroblasts depends on the levels of ANGII in the cells. In normal fibroblasts, AGTR1 activates ANGII through the primary manner. However in activated (myo) cells AGTR2-positive cells, they contribute to the process of fibrosis. This gene regulates the function of fibroblasts and may be a therapeutic target.
The levels of fibroblasts in healthy and fibrotic lung tissues are also different. The treatment with AngiI increased the basal fibroblasts of the lung and AGTR2 inhibition reduced the levels of bleomycin treated fibroblasts. The inhibition of AGTR1 reversible these effects. Pretreatment with LOS or PD did not alter the angiI-mediated fibroblast growth.
Boster's gene infographics provide basic information on each gene. This gene infographic includes details on all the human and mouse genes. A gene search bar is available in the product, which allows you to locate exactly the gene that you are looking for. Genes are classified according to genes and related functions and are accompanied by pictures and a description. In addition each gene is given a useful label that allows you to quickly and easily determine the function of the product.
The story of Steven Boster traces his career through 1993, when he first developed his product. He was known as "the man who converted science in the lavatory" and soon came up with a variety of products for immunohistochemistry (IHC). He was responsible for the creation of hundreds of primary antibodies, and was the largest antigen catalog company in China during the 1990's. He had diversified his product offerings to include PicoKine(tm) is a proprietary ELISA platform that provides high-sensitivity ELISA kits.
In addition to being an ex- NFL player, Steve Boster was a member of Concordia Hall in Staunton, VA. He was ordained a minister and served for over 30 years in the United States Army. He is survived by two daughters Natosha and Crystal Boster, 6 Grandchildren four brothers (Jack, Jack, and Steve), four sisters, and a multitude of nieces and nephews.
PMID: 7733925 by Martin M.M., et al. The sequence and genomic organization of the human type 2 angiotensin II receptor.
PMID: 7790004 by Chassagne C., et al. Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization.
*More publications can be found for each product on its corresponding product page