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- Table of Contents
Facts about Adenylate kinase isoenzyme 1.
Plays an essential role in cellular energy homeostasis and in adenine nucleotide metabolism. .
Human | |
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Gene Name: | AK1 |
Uniprot: | P00568 |
Entrez: | 203 |
Belongs to: |
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adenylate kinase family |
adenylate kinase 1; adenylate kinase isoenzyme 1; AK 1; ATP-AMP transphosphorylase 1; EC 2.7.4; EC 2.7.4.3; myokinase
Mass (kDA):
21.635 kDA
Human | |
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Location: | 9q34.11 |
Sequence: | 9; NC_000009.12 (127866480..127885542, complement) |
Cytoplasm.
Are you looking for an antibody that is a primary one against the Marker AK1? Boster offers the high affinity antibodies you need. The antibodies have been validated by the scientific community and are supported by decades of research. Boster antibodies have been validated for use in immunohistochemistry, ELISA, and Western Blotting. If you're in search of an antibody to the AK1 Marker for cancer research or fibrosis, Boster has a product that will satisfy your requirements.
The most effective uses for the AK1 marker stem mainly from human genomes. The marker is used to study the chromosome10 assembly. AK1 BAC library reveals that most of the AK1 Clones are extremely concordant with the assembly. 99.8 percent of AK1 BAC clones aligned to the reference genome. The majority of differences are due to differences in phase.
To sequence AK1 ABACs, genomic DNA was extracted using the Gentra Puregene Cell Kit from Qiagen. Genomic DNA was cut using the Covaris G-TUBE up to a size of 20 kb. The genomic DNA was subjected repair of DNA damage with blunt-end adaptor ligation. Next, the genomic DNA was subjected exonuclease digestion. This was followed by blunt-end adaptor binding to create a high quality reference for sequencing.
The AK1 gene was expressed at a significantly higher level in transgenic mice than in wild-type mice, indicating that the transgene overexpression results in an increase in AK1 activity. Although AK1 is a vital gene in human development and cell survival, it is not identified if it has any effect on I/R injuries or cell survival. It is not known if transgene expression increases the protective effects of AK1.
The AK1 marker can be used to aid in clinical decision-making, allowing physicians to identify patients with leukemia. Some studies have shown poor outcomes for patients suffering from AML due to the mutational status of AK1. The role of AK1 as a prognostic indicator in the disease is yet to be determined. The information will be available on the TCGA website. It is unclear how AK1 will aid doctors in making informed decisions about patients and their treatment.
This protein even though it has potential uses is not an exact indicator of mitochondrial power in all its forms. The AK system is a metabolic redundancy, however, it gains importance in physiologic terms when other phosphotransfer systems fail. The AK1 gene does not have a cardiovascular protection in normal conditions. However it plays a significant role in the homeostasis of energy. It also regulates local concentrations adenine nucleotides.
The enzyme AK1 plays an essential part in the energy metabolism. There are nine distinct adenylate-kinase enzymes found in the human body. They are named in accordance to the order in which they were discovered. The AK1 enzyme plays a crucial role in neuronal renewal and myocardial energy homeostasis and cell cycle stoppage. These enzymes are found in a variety of tissues and play an essential role in the regulation and activation of the p53 gene , as well as the cellular phosphotransfer network.
The unique features of the AK1 allow it to be pulled behind a car with a light trailer and can easily be towable on roads that are rough. Whether you are using the AK1 as an operational or hunting rifle, you'll appreciate its high-quality construction and low-cost parts. The AK1 can be easily taken apart and serviced for repairs. The five-position stock lets shooters adjust the pull of the gun to fit their preferred shooting style.
Although it is not clear whether AK1 Marker is a definite marker for fibrosis, there are a variety of tests that can be used to detect patients with liver fibrosis. A recent UpToDate review suggests that the use of a serum marker is not a reliable alternative to a more thorough liver examination. A fibrosis marker should be biologically based specific, noninvasive, and easily repeated in all patients without the risk of confounding variables like drug and co-morbidity. There are some limitations to serum tests for Fibrosis.
Serum markers aren't effective in diagnosing fibrosis. They can also indicate locations of inflammation that are also susceptible to fibrosis. They could also be a sign of the excretion of biliary fluid or sinusoidal endothelial dysfunction. They are not diagnostic instruments and are only used as surrogates. Further, the serum markers don't indicate the presence of fibrosis.
Serum markers can be employed to replace liver biopsy, despite the limitations. Serum markers can be used to improve the accuracy of diagnostic tests and as early tests for diagnosing fibrosis. However, the researchers have discovered a major weakness in the absence of common performance indicators or diagnostic odds ratios. Therefore, the tests have not yet been widely accepted as a substitute for liver biopsy.
Fibrospect II is a medical test to detect fibrosis in the liver. Prometheus Laboratories, California, developed it. It is a single-point blood test and employs three serum markers, a-2-M and HA. Fibrospect II can detect and exclude significant fibrosis . It has a positive predictive value.
The AK1 marker is an excellent alternative for diagnosing fibrosis. Researchers have developed a standard test to measure AK1 levels. This test is used to assess the progress of liver fibrosis. It is also used to detect non-alcoholicfatty liver disease. However some researchers are not sure if AK1 is an accurate fibrosis marker.
The serum level of MFAP4 is not raised in patients with pulmonary fibrosis or mice treated with Bleomycin. However, there is some evidence that suggests that MFAP4 may be a useful biomarker for hepatic and lung fibrosis. However, more research is required to confirm these preliminary findings. AK1 is an inflammatory cytokine that has been linked to several other inflammatory conditions, such as lung fibrosis.
Based on the kind of cancer, AK1 Marker may not be present in your cancer. Tumor markers are used to determine whether treatment is effective. These tests can be carried out on urine, blood, and tumor samples. This test can also show the effectiveness of treatment by determining whether a cancer has returned. If you are worried about the results, speak about the results with your health care doctor. In addition, you should be aware that tumor markers may be falsely positive, indicating that cancer is present, while false negatives indicate that no cancer is present. It is crucial to be aware of these tests before you undergo them.
The National Academy of Clinical Biochemistry published a guideline for the use of cancer markers in clinical practice. The guideline, called Use of Tumor Markers In Clinical Practice, focused on how to use tumour markers for specific cancers. In addition to the guideline, the National Cancer Institute has published guidelines for the collection, processing and storage of biospecimens. The guidelines recommend the collection of biospecimens as well as provide detailed instructions about how to collect them.
Tumor markers can be useful for cancer treatment planning and monitoring response. They can also be used to detect recurrence and other symptoms. The results of tests for these tumor markers must be evaluated in conjunction with your physician's examination and symptoms, as well as radiological studies. The following table lists the possible tumor markers and non-cancerous conditions that could cause high levels of these markers. It also lists the usual results for each tumor marker.
A tumor marker is necessary for most cancer treatments. They can provide a myriad of benefits, such as determining the nature of the cancer as well as the rate of treatment. The most effective tumor markers are ones that are precise and precise. They are helpful in cancer screening and can help to determine the severity of a certain kind of cancer and how it responds to treatment. So, if you have cancer, an AK1 Marker test could be the right choice for you.
CA 19-9, the seven-2.2 kDa antigen that is associated with cancer-related carbohydrate, is an emerging marker. It was initially found in pancreatic and colon cancer patients and patients with pancreatic cancer, CA 19.9 aids cancer cells in adhering to the endothelium. This cancer marker can also be found in some nonmalignant conditions that include pregnancy and AIDS. However, the American Society of Clinical Oncology disapproves of the use of this marker as screening tests. The amount of CA 19.9 is closely linked to the size of the tumor.
There are numerous cancer markers. Tumor markers are substances found in the body that are created by cancerous or healthy cells in response to the tumor. These markers can be found in urine, blood tissues, as well as other body tissues. While certain markers are specific to a specific type of cancer, other are linked to a variety of kinds. If your cancer is manifested by increased levels of AK1 Marker Your treatment team should be able to identify the type of cancer present in your body.
PMID: 183954 by von Zabern I., et al. Primary and tertiary structure of the principal human adenylate kinase.
PMID: 2542324 by Matsuura S., et al. Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.