AKR1C4 Antibodies

AND AKR1C4 ELISA kits, AKR1C4 Proteins

Many biological assays use antibodies to detect AKR1C4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1C4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1C4 antibodies...

We validate the specificity of these antibodies to AKR1C4 by testing them on tissues known to express AKR1C4 positively and negatively. Browse below to find the AKR1C4 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AKR1C4 Infographic by Boster Bio

All AKR1C4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human AKR1C4 ELISA Kit PicoKine®

5 Q&As

Human

ELISA

$750
Cat # EK1870
96 wells/kit, with removable strips.

Anti-AKR1C4 Antibody

Western blot analysis of extracts of various cell lines, using AKR1C4 antibody at 1:1000 dilution

Human, Mouse, Rat

$405
Cat # A05174
100ul

AKR1C4 (NM_001818) Human Recombinant Protein

Coomassie blue staining of purified AKR1C4 protein

$1249
Cat # PROTP17516
20 µg

AKR1C4 (NM_001818) Human Over-expression Lysate

Human

$628
Cat # LS001109
20 µg, 100 µg

Anti-AKR1C4 Antibody

Human, Mouse, Rat

ELISA, WB

$370
Cat # A05174-2
100 μl/vial

AKR1C4 Overview

Facts about Aldo-keto reductase family 1 member C4.

AKR1C4 3D structure. Source: alphafold

Aldo-keto reductase family 1 member C4 (AKR1C4)

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) to the active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity.

The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant loss of its neurotoxicity because bile is the main excretory route. .

Gene Information

Human
Gene Name:	AKR1C4
Uniprot:	P17516
Entrez:	1109

Family

Belongs to:

aldo/keto reductase family

Alternative Names

3-alpha-HSD; AKR1C4; Aldo-keto Reductase 1C4; aldo-keto reductase family 1, member C4; AldoketoReductase 1C4; C11; CDR; CHDR; DD4; DD-4; HAKRA

Molecular Weight

Mass (kDA):
37.067 kDA

Genomic Context


Human

Location:	10p15.1
Sequence:	10; NC_000010.11 (5196837..5218949)

Tissue Specificity

Liver specific.

Subcellular Localizations

Cytoplasm.

Diseases

Malignant Neoplasms
Mammary Neoplasms
Malignant Neoplasm Of Breast
Carcinoma
Malignant Neoplasm Of Prostate
Prostatic Neoplasms
Renal Cell Carcinoma
Osteoporosis
Adenocarcinoma
Liver Carcinoma
Endometrial Polyp
Manic
Malignant Neoplasm Of Lung

Bipolar Disorder
Lung Neoplasms
Neoplasm Metastasis
Malignant Tumor Of Colon
Kidney Neoplasm
Constipation
Endometriosis, Site Unspecified

Pathways

Sulfation
Cell Proliferation
Lactation
Parturition
Cell Growth
Estrus
Ovulation

Pathogenesis
Conjugation

PTMs

Reduction

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1C4

References

PMID: 8274401 by Qin K.-N., et al. Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PMID: 7650035 by Khanna M., et al. Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.