Aldo-keto reductase family 1 member C4 (AKR1C4)

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) to the active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity.

The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant loss of its neurotoxicity because bile is the main excretory route. .