Secretogranin-1 Antibodies

AND CHGB ELISA kits, Secretogranin-1 Proteins

Many biological assays use antibodies to detect Secretogranin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Secretogranin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Secretogranin-1 antibodies...

We validate the specificity of these antibodies to Secretogranin-1 by testing them on tissues known to express CHGB positively and negatively. Browse below to find the CHGB antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Secretogranin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the CHGB Western Blot Guide

CHGB Infographic by Boster Bio

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Anti-Chromogranin B CHGB Monoclonal Antibody

Western blot analysis of Chromogranin B/CHGB using anti-Chromogranin B/CHGB antibody (M04073)

Human, Mouse, Rat

$370
Cat # M04073
100 μl

CHGB Overview

Facts about Secretogranin-1.

CHGB 3D structure. Source: alphafold

Secretogranin-1 (CHGB)

Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. .

Gene Information

Human
Gene Name:	CHGB
Uniprot:	P05060
Entrez:	1114

Family

Belongs to:

chromogranin/secretogranin protein family

Alternative Names

CgB; CHGB; chromogranin B (secretogranin 1); Chromogranin B; Chromogranin-B; SCG1; SCG1sgI; secretogranin B; Secretogranin I; secretogranin-1; SgI

Molecular Weight

Mass (kDA):
78.276 kDA

Genomic Context


Human

Location:	20p12.3
Sequence:	20; NC_000020.11 (5911510..5925353)

Tissue Specificity

Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Subcellular Localizations

Secreted. Neuroendocrine and endocrine secretory granules.

Diseases

Pituitary Diseases
Neoplasms
Pheochromocytoma
Disease Of Adrenal Medulla
Pituitary Neoplasms
Schizophrenia
Adenoma
Adrenal Gland Neoplasms
Pituitary Adenoma
Pancreatic Neoplasm
Hypertensive Disease
Neuroendocrine Tumors
Carcinoma

Amyotrophic Lateral Sclerosis
Malignant Neoplasms
Dysequilibrium Syndrome
Insulinoma
Carcinoid Tumor
Prolactinoma
Neuroblastoma

Interacting Proteins

FAM20C
LRRK2
SMAD2

Pathways

Secretion
Localization
Exocytosis
Hormone Secretion
Secretory Pathway
Proteolysis
Translation
Regulated Secretory Pathway
Transport
Insulin Secretion

Response To Gonadotropin-releasing Hormone
Cell Differentiation
Pathogenesis
Excretion

PTMs

Cleavage
Phosphorylation
Sulphation

Biotinylation
Amidation
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHGB

References

PMID: 3608978 by Benedum U.M., et al. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region.

PMID: 1882087 by Gill B.M., et al. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing.