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- Table of Contents
Facts about ALK tyrosine kinase receptor.
Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction.
Human | |
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Gene Name: | ALK |
Uniprot: | Q9UM73 |
Entrez: | 238 |
Belongs to: |
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protein kinase superfamily |
ALK tyrosine kinase receptor; ALK; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; anaplastic lymphoma receptor tyrosine kinase; CD246 antigen; CD246; EC 2.7.10.1; Ki-1; NBLST3; Tcrz
Mass (kDA):
176.442 kDA
Human | |
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Location: | 2p23.2-p23.1 |
Sequence: | 2; NC_000002.12 (29190992..29921589, complement) |
Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
Cell membrane; Single-pass type I membrane protein. Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
This article will help you make the best ALK marker use for your research. This article examines the research of Boster Bio, which includes its ELISA kits as well as PICOKINE (tm) antibodies. We will also examine the history of Steven Boster as well as the company's products. Boster Bio's history is something you might be interested in.
Boster Bio's specialty is the development and testing of multiplex ELISAs and primary and secondary antibodies. Boster Biomarkers can be detected in cancer, neurosciences and developmental biology by Boster Biologicals at a picogram level. The company provides multiplex immunohistochemistry services and has more than 5,000 IHC publications. Visit tebu.bio for more information on Boster Bio.
Secondary antibodies improve the efficiency of various experimental techniques. They are produced by immunizing host animals with antibodies from other species. Secondary antibodies recognize the immunoglobulin Ig domain of a primary antibody. They aid in purification, sorting and detection of target antibodies. Secondary antibodies are usually coupled with a tag. The downstream application will decide the label. Indirect detection is superior to direct detection of proteins using primary antibodies.
Boster Bio's research ELISA for ALK marker allows researchers the ability to determine whether a protein is active in a tumor cell. The ELISA kit is sensitive to picograms, making it ideal for detection of biomarkers in a variety biological tissues. Boster Bio-Technology, located in Wuhan China. They also produce antibody kits that can be used to detect other biomarkers such as inflammation, cancer, and neuroscience.
The Human fetuin – A PicoKine(tm), ELISA kit was designed to measure the level this ligand in cell supranatants. Boster Biological Technology produced the kit. The anti-human fetuin-A antibody was added to 100 ul of cell culture supernatants. The samples were incubated at 37 degrees Celsius for 30 minutes.
Steve Boster was created June 26, 1925 in Joliet Illinois. He was a successful retail sales manager for many years. He served in the U.S. Army. He was a Concordia Hall Member in Staunton. Steve is survived by Crystal Boster and Natosha. He is survived six grandchildren, four brothers, as well as many nieces and nephews.
In 1993, Steven Boster released his first product. By then, he had hundreds and hundreds of primary antibodies. He was China's largest antibody catalog by the end of the 1990s. PicoKine(tm), a patented ELISA system, was created by him. This platform utilized proprietary trade secrets to provide high-sensitivity ELISA kits.
PMID: 9174053 by Morris S.W., et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non- Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).
PMID: 9053841 by Iwahara T., et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.