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- Table of Contents
1 Citations 4 Q&As
Facts about Alpha-amylase 1.
Human | |
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Gene Name: | AMY1A |
Uniprot: | P04745 |
Entrez: | 276 |
Belongs to: |
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glycosyl hydrolase 13 family |
1,4-alpha-D-glucan glucanohydrolase 1; alpha-amylase 1; AMY1; AMY1B; AMY1C; amylase, alpha 1A (salivary); amylase, alpha 1A; salivary; amylase, salivary, alpha-1A; EC 3.2.1.1; glycogenase; Salivary alpha-amylase; salivary amylase alpha 1A
Mass (kDA):
57.768 kDA
Human | |
---|---|
Location: | 1p21.1 |
Sequence: | 1; NC_000001.11 (103655519..103664551) |
Secreted.
Boster scientists can submit their findings for species, special samples and applications. They can also earn product credits based upon their results. These credits are available to all scientists from around the world. They are among the most popular applications of the AMY1A mark. Continue reading to find out more about these applications. There are other applications, too. Learn how to use the AMY1A gene in your research.
There are hundreds of thousands of regions of the human genome that are containing copy number variation (CNV). Because these changes are often extremely rare, their effects on phenotypes are not completely understood. To address this issue researchers have developed a computer-based method that exploits the abundance of haplotype sharing among biobank cohorts to detect co-inherited CNVs. This algorithm improved CNV detection sensitivity six-fold, and could explain half of rare gene activation events caused by structural changes in the genome.
"Copy number variation" refers, among others, to differences in the number of copies of a particular segment of DNA. It can happen within genes as well as long stretches of DNA. This can cause a variety of illnesses and health risks. Due to this, copy variation in numbers is a key source of genomic variation. Boster bio copy number variations can be detected by genetic testing. The test determines copy numbers variation in Boster bio and can help determine the best treatment for a patient.
It is a long-standing tradition to identify variation in copy number within individuals. It is a constant research priority. By studying the variations in individual genomes, we can determine whether there are any other genetic risk factors, such as gene expression. CNVs are responsible for a large portion of the genetic variation that occurs in humans. Therefore, they could play a role in phenotypic variation, and disease susceptibility.
CNVs are prevalent in humans and may be a factor in the diversity of phenotypic traits and variable susceptibility to complex disease. Utilizing two array-based comparative genomic hybridization tools, researchers have identified 355 CNVs in 20 chimpanzees born in the wild. Many of these variants are located at the same location. Some loci have been found to be over-enriched by 20-fold. This could indicate a larger population-wide effort in copy number analysis.
The AMY1A gene has a high connection to the development of diabetes however, a lot of research is required before it can be applied to an actual clinical trial. It is good news that there are many ways to use this gene to determine the underlying causes of diabetes. Researchers at Boster Bio are developing new tests to detect this gene, and we'll be reviewing some of these methods in this article.
Using Mendelian randomization, the researchers tested the association between BMI and the AMY1A marker in a large, prospective study. We looked at the metabolite profile of participants using iSelect Metabochip DNA microarrays created by Illumina. To control for age, sex and alcohol consumption per day the two primary components of ethnicity were adjusted. After adjusting for these factors the analysis was conducted using a linear regression model.
AMY1A is a gene that is involved in the regulation and maintenance of insulin resistance in humans. The gene is expressed by the pancreas in response an increase in insulin levels and is associated with the presence of a variety of illnesses. The gene is also referred to by the acronym ADAMTS3. Although there are many other markers of insulin resistance The AMY1A marker is particularly helpful in diagnosing insulin resistance.
This gene is a great one with many benefits. High AMY1A copies are less likely to develop diabetes or insulin resistance. They have lower postprandial glucose response. However, a flaw of the method employed in the study makes it difficult to draw conclusions from it. The study will determine if the AMY1A gene is involved in diabetes development.
The AMY1A gene copy number is variable. The number of copies ranges from three to seven. The copy number of the AMY1A gene is related to the level of a-amylase activities in the cell. This gene copy number also is related to the expression level of a-amylase. It may also indicate insulin resistance in diabetics.
It isn't yet clear what the AMY1A marker can be used to predict the onset of Alzheimer’s disease. However, it is an attractive gene to test for Alzheimer's disease since it can be used to detect the onset and progression of Alzheimer's disease. The gamma secretase complex comprised of four genes. These genes are grouped together to create an active enzyme in mammalian cells.
PMID: 2423416 by Nishide T., et al. Primary structure of human salivary alpha-amylase gene.
PMID: 6610603 by Nakamura Y., et al. Corrected sequences of cDNAs for human salivary and pancreatic alpha- amylases.
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