Serum amyloid P-component Antibodies

Serum amyloid P-component (APCS)

Can interact with DNA and histones and might scavenge nuclear material released from cells that are damaged. May also function as a calcium-dependent lectin.

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Gene Information

Human
Gene Name:	APCS
Uniprot:	P02743
Entrez:	325

Family

Belongs to:
pentraxin family

Alternative Names

9.5S alpha-1-glycoprotein; amyloid P component, serum; APCS; MGC88159; Pentraxin 2; PTX2; PTX2serum amyloid P-component; SAP; SAPpentaxin-related; Serum Amyloid P component

Molecular Weight

Mass (kDA):
25.387 kDA

Genomic Context

Human
Location:	1q23.2
Sequence:	1; NC_000001.11 (159587826..159588865)

Tissue Specificity

Found in serum and urine.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Lupus Erythematosus, Systemic
• Corneal Diseases
• Neoplasms
• Charcot-marie-tooth Disease
• Polyneuropathy
• Down Syndrome
• Hemorrhage
• Pain
• Spinal Muscular Atrophy
• Pathologic Neovascularization
• Hematologic Neoplasms

• Autoimmune Diseases
• Diabetes Mellitus
• Heart Diseases
• Blood Loss, Surgical
• Stenosis
• Amyloid Neuropathies, Familial

Pathways

• Cell Proliferation
• Pathogenesis
• Transport
• Cell Adhesion
• Insulin Secretion
• Aging
• Metaphase
• Symport
• Cell Division
• Flight
• Antiport

• Amino Acid Transport
• T Cell Proliferation
• Biological Regulation
• Cell Differentiation
• Cell-cell Adhesion
• Secretion

PTMs

• Disulfide bond

• Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APCS

Best Uses Of The APCS Marker From Boster Bio

Boster has been producing high-affinity primary antibodies for over 25 years. These antibodies are highly cited in the research community and validated on Immunohistochemistry, Western Blotting, and ELISA. Learn how to make use of the APCS Marker. This marker can also be used in other ways. We've collected a few of our favorite markers.

APCS Marker

The APCS marker is a fluorescent red fluorophore that is extensively used in flow cytometry. It is extremely efficient at transmitting light, however, it is dim and prone to photo bleaching and pH. It is recommended to use with markers that are highly expressed. To get the most out of APCS markers you should read the following. Below are some examples of these applications, along with additional information. APCS is a fluorescent-red fluorophore with an extinction coefficient at 700,000 cm-1 M-1.

CD40

The APCS marker is a fluorescence molecule of the red color. It is used in flowcytometry to identify different populations of leukocytes. Flow Cytometers are capable of measuring up to ten colors in one sample. Modern cytometers can monitor up 18 channels simultaneously. This makes it an excellent choice in flow cytometry. These are among the most popular uses for the APCS marker.

The study analysed 81,643 APCS. Two sets of COVID-19 patients were studied. To determine APCs, graph-based Clustering as well as community discovery and nonlinear dimensions reduction were used. Manual annotation using canonical marker markers for genes resulted in the map of APC subsets within HCs and COVID-19.

CD34

The APCS marker is an immunofluorescence protein that has red fluorescence. It is more bright than Cy5, which makes it a good marker for flow cytometry. In addition to its brightness, the APC is useful for identifying intracellular and intracellular targets. Numerous researchers have demonstrated that the APCS marker can be used in various ways. Here are some of the most popular uses for the APCS marker.

APCs were extracted from COVID-19 patients as well as healthy donors. The patient population was characterized with an autoimmun-related COVID-19. The 10X Genomics facility sequenced APCs. Each subset was identified using UMAP and doughnut plots. The severity of COVID-19 was correlated with APC subtypes. Here, APC subtypes are discussed and the associated genes are shown.

One study found that the majority of CD1a-expressing APCs were located in the paracortex, while CD14-expressing cells were located in the medulla. In contrast, CD68+ APCs were found in diffuse T-lymphocyte areas of the paracortex. This study also demonstrated that APCs expressing CD209 were located in the medulla.

The APCS marker is able to detect the presence of the antigen within various tissues. The marker can be used for a variety applications, including immunodiagnosis. This marker is particularly useful in identifying infected tissues and cells. APCS can also be used to monitor the spread and spread of infections in humans. The APCS marker can be used for a variety of purposes and is an effective tool.

CD11b

The CD11b APCS marker recognizes the antigen CD11b, also known as Integrin aM chain, CR3A, or C3biR. It is expressed on the surface of many cells and is a key regulator of several pathways, including cytokine signaling, toll-like receptor 4 (TLR4), and apoptosis. It is also involved in the generation of superoxide anion and promotes microglial cell mediated cytotoxicity. Flow cytometry has also begun using this marker.

The CD11b APCS marker is associated with a worse outcome in patients with gastric cancer with high CD11b cell count. Kaplan-Meier survival curves showed that patients with high CD11b+ cancer-infiltrating tumor cells had a worse prognosis than those with lower CD11b levels. Cox models that assessed overall survival and infiltrating patterns showed that high CD11b+ APCs have a negative impact on outcomes. Gastric cancer cell lines also produced the cytokines that suppressed and stimulated by DCs.

This marker can also be used for distinguishing between MDCs and PDCs. CD11b+ MDCs are frequently found in peripheral blood and CD11b+ MDCs constitute the largest portion of this subset. Additionally, CD11b+ B cells are also a subset of MDCs. Using the CD11b APCS marker is highly recommended, especially in the context of immunohistochemistry.

In a recent study, CD11b APCS cells of mice suffering from EAE were sorted and studied. CD45+ cells, monocytes and cDCs were taken from spinal cords of C57BL/6J mice who were born. The spinal cords of mice were also removed from monocyte-derived APCs , and then counted. Following that, bone marrow cell were separated from the femur and tibia.