Apolipoprotein B-100 Antibodies

Apolipoprotein B-100 (APOB)

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles from the apoB/E receptor.

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Gene Information

Human
Gene Name:	APOB
Uniprot:	P04114
Entrez:	338

Family

Belongs to:
No superfamily

Alternative Names

Apo B-100; APOB; ApoB-100; ApoB-48; apolipoprotein B (including Ag(x) antigen); Apolipoprotein B; apolipoprotein B-100; apolipoprotein B48; FLDB; LDLCQ4; mutant Apo B 100

Molecular Weight

Mass (kDA):
515.605 kDA

Genomic Context

Human
Location:	2p24.1
Sequence:	2; NC_000002.12 (21001429..21044073, complement)

Subcellular Localizations

Cytoplasm. Secreted.

Diseases

• Hypercholesterolemia
• Hypercholesterolemia, Familial
• Hyperlipoproteinemia Type Iib
• Coronary Heart Disease
• Heart Diseases
• Hypobetalipoproteinemias
• Familial Hypobetalipoproteinemia
• Atherosclerosis
• Cardiovascular Diseases
• Coronary Artery Disease
• Hyperlipoproteinemia Type Iia
• Fatty Liver
• Hyperlipidemia

• Variable Number Tandem Repeat
• Obesity
• Myocardial Infarction
• Dyslipidemias
• Diabetes Mellitus
• Infarction
• Hypertensive Disease

Interacting Proteins

• LDLR

Pathways

• Secretion
• Transport
• Cholesterol Homeostasis
• Lipid Transport
• Pathogenesis
• Localization
• Gallstone Formation
• Gene Silencing
• Platelet Aggregation
• Cell Death
• Glucose Homeostasis
• Cholesterol Efflux
• Excretion

• Intestinal Absorption
• Translation
• Mrna Transcription
• Metaphase
• Endocytosis
• Rna Splicing
• Rna Interference

PTMs

• Cleavage
• Deamination

• Glycosylation
• Methylation

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APOB

Best Uses Of The APOB Marker

A thorough overview of Steven Boster and APOB markers will help you determine whether this genetic testing kit is suitable for you. The article below also covers genetic infographics and the history behind them. If you are a scientist who wants to learn more about this genetic marker Boster's biographics are an essential read. However, if already decided that this test is for you, keep reading to learn how to utilize it.

Marker APOB

The APOB (acid-phosphate-binding) protein (APOB) is a key component in the process of enzyme catalysis. The APOB protein is used to form a chemically reacting compound. APOB protein is a fluorescent marker that allows the detection of amino acids, which comprise proteins. Apart from being a reliable indicator of enzyme activity APOB is also a crucial element in many cell lines and tissues.

Gene infographics

Although the APOB marker's presence has been linked to EOAD in several studies, no single genetic variant has been shown increase the risk of EOAD. The data set used in the study to determine the marker included 381 samples as well as the genetic, sex and primary components. The effect sizes were 0.26, 0.21, and 0.02 respectively. The replication data set from UCSF contained only 173 samples.

These findings suggest a link between elevated LDL C levels and EOAD risk, however other factors could also be contributing to these differences. Other genetic variants associated with EOAD in addition to the APOB marker have not yet been identified. More research is required to determine if this gene may contribute to the development of EOAD. The APOB gene codes for an important protein in LDL-C which is involved in the development of the disease.

Researchers have identified the ApoB/ApoA1 gene as a biomarker that indicates higher risk of cardiometabolic disease and worse clinical outcomes in JSLE patients. These gene infographics can also be used to identify patients who require additional monitoring for their condition and lifestyle modifications or lipid modification. The APOB gene encodes a distinct protein that can be found in human blood cells. It is a type of protein known as apolipoprotein B.

History

A recent study has demonstrated that the APOB marker has more predictive value for CHD risk than LDL cholesterol, non-HDL cholesterol, or total cholesterol. It identified a subset high-risk patients that have low levels of other markers, and may eventually replace the current cholesterol measurements. The background of the APOB marker remains unclear. Researchers aren't quite sure if this gene is directly related to CHD risk.

Although no one is certain when the gene was first discovered, there is evidence that this gene has a long history. In 1997, Myant et al. Myant and colleagues. estimated the rate of recombination that occurs between chromosome 2 markers and the APOB gene in 1997. They observed significant linkage disequilibrium between APOB gene marker D2S220 and three YACs.