This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
7 Q&As
Facts about Rho GDP-dissociation inhibitor 1.
Retains Rho proteins like CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the mobile, mediates extraction from membranes of both inactive and activated molecules due its exceptionally significant affinity for prenylated forms.
Human | |
---|---|
Gene Name: | ARHGDIA |
Uniprot: | P52565 |
Entrez: | 396 |
Belongs to: |
---|
Rho GDI family |
GDIA1; MGC117248; Rho GDI 1; Rho GDP dissociation inhibitor (GDI) alpha; rho GDP-dissociation inhibitor 1; Rho-GDI alpha; RHOGDI; RHOGDI-1
Mass (kDA):
23.207 kDA
Human | |
---|---|
Location: | 17q25.3 |
Sequence: | 17; NC_000017.11 (81867719..81871337, complement) |
Cytoplasm.
PMID: 8262133 by Leffers H., et al. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.
PMID: 8504089 by Kwong C.H., et al. Regulation of the human neutrophil NADPH oxidase by rho-related G- proteins.