Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Retains Rho proteins like CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the mobile, mediates extraction from membranes of both inactive and activated molecules due its exceptionally significant affinity for prenylated forms.