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- Table of Contents
Facts about Aryl hydrocarbon receptor nuclear translocator-like protein 1.
It is derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide variety of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in virtually every tissue and organ system.
Human | |
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Gene Name: | ARNTL |
Uniprot: | O00327 |
Entrez: | 406 |
Belongs to: |
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No superfamily |
aryl hydrocarbon receptor nuclear translocator-like protein 1; aryl hydrocarbon receptor nuclear translocator-like; basic-helix-loop-helix-PAS orphan MOP3; BHLHE5; bHLHe5brain and muscle; bHLH-PAS protein JAP3; BMAL1TIC; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; Member of PAS protein 3; member of PAS superfamily 3; MOP3BMAL1c; PAS domain-containing protein 3; PASD3MGC47515
Mass (kDA):
68.762 kDA
Human | |
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Location: | 11p15.3 |
Sequence: | 11; NC_000011.10 (13276552..13387268) |
Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
Nucleus. Cytoplasm. Nucleus, PML body. Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2.
ARNTL is a translocator nuclear that binds a variety of proteins. The ARNTL mark can be used in a variety biology assays, including those that examine fatty acid metabolism. You can read on to learn more. Learn how to use this marker in your own research. Continue reading to learn more about the best uses for the ARNTL marker.
ARNTL is a nucleotide translocator ortholog for the human gene, CLOCK. To promote repression the protein interacts directly with transcription factors in your nucleus. In vitro, it interacts with the transcription factor AHR and HSP90. It is thought to be involved in circadian rhythms. The human ARNTL genome is located in the exact same region as its ortholog, the Cycle.
ARNTL (an essential cellular protein) is involved in regulation of myogenesis. It regulates the expression of insulin and the canonical Wnt signaling pathway. ARNTL regulates PRC2 and adenylate cyclase types 1 (ADECY).
Previous studies suggest that Arntl may be involved in the regulation and maintenance of blood pressure. Arntl mRNA levels have been found to be lower in hypertensive women than the control group in a study. The authors found that mRNA expression of ARNTL negatively correlated with both SBP and DBP. However, few studies have investigated the transcription levels of Arntl mRNA. To date, genetic evidence of Arntl's existence has largely focused on locus variability. Nonetheless, Li et al. reported that patients with Arntl A1420G genotype had high SBP at night.
The Picoband (tm) catalog includes the Boster Bio Anti BMAL1/ARNTL Antibody. This antibody reacts with Human and is stable at -20 and 4 degrees Celsius. The product contains 5% BSA, 0.9mg NaCl, and 0.05mg NaN3 per vial. It can keep at -20 degrees Celsius for 1 year and at 4° Celsius for 1 month. The bosterbio ARNTL antibody is contained in a vial containing five mg of BSA. It also contains 0.09 mg NaCl and 0.05 mg NaN3 for optimal stability.
The bifunctional ARNTL–CLOCK ARNTL-CLOCK heterodimer regulates adult neurogenesis. Through the transcriptional repressor PER1/2, the ARNTL–CLOCK complex regulates gene expression. It is also essential in the regulation of the diurnal rhythms of skeletal muscle metabolism. It is also involved in the regulation transcriptional activators.
The ARNTL genome encodes a protein that is known as aryl Hydrocarbon Receptor Nuclear Translocator-Like. It forms a heterodimer with CLOCK and induces transcription of genes called Period and Cryptochrome. Both CRY, BMAL and ARNTL are transcription factors that interact with each other. Both transcription factors are involved in the auto-regulatory transcription/translational feedback loop. A defective ARNTL-gen is associated infertility as well as problems with gluconeogenesis.
ARNTL/BMAL1 is a key regulator of circadian gene expression in human and mouse neurogenesis. ARNTL/BMAL1 regulates canonical Wnt signaling pathways, insulin secretion, Ly6C monoocyte rhythms, and insulin secretion. This transcription factor also negatively affects the expressions of MTOR/DEPTOR. Among many other functions, ARNTL/BMAL1 regulates activity of many transcription factor.
ARNTL is an ASS1-binding transcription factor. The ARNTL/BMAL1 homodimer activates clock genes with E-box motif promoters. In addition, it regulates CLOCK-mediated acetylation of ASS1 and the transcription of the immune checkpoint protein CD274. It is also involved with circadian rhythms in skeletal muscle metabolism. It promotes the synthesis triglycerides.
ARNTL is a HLH containing transcription factor that regulates expression of E-box motif containing genes. ARNTL has been found to be epigenetically suppressed in many human cancers. Recent research showed that ARNTL overexpression restored the rhythmic activity in ovarian carcinoma cells and inhibited growth. These results suggest that ARNTL could function as a tumor suppressor.
Santa Cruz Biotechnology, Inc., (SCBT) is one of the most prominent suppliers of research antibody. It was established in 1991. The company focuses its efforts on the production of primary and specific antibodies for the study of diseases. Santa Cruz Biotechnology also provides a wide range general chemical products and reagents. This company maintains the highest quality standards. Its products are available at three locations in America and one in Germany.
Santa Cruz Biotechnology has also settled a class-action lawsuit brought by Stop Animal Exploitation Now. The lawsuit was filed January 17, 2013 and was settled by the company. Santa Cruz Biotechnology produces research antibodies that are used in thousands across the globe. These antibodies can be used to help scientists develop new treatments for disease. The company is also involved as a researcher and developer of products for animal usage. The company has not disclosed the specific uses of its products.
The company has been involved in animal welfare issues for a long time. The U.S.D.A. found evidence in 2003 that Santa Cruz Biotechnology used animals for animal-welfare purposes. The U.S.D.A. uncovered evidence that Santa Cruz Biotechnology used animals with poor veterinary care, and euthanized them. The company then obtained antibodies from more than 1,000 rabbits, goats, and other animals without their consent. According to the company only eighty rabbits were in its possession. In 2007 another citation was issued for insufficient veterinary care.
PMID: 9144434 by Ikeda M., et al. cDNA cloning and tissue-specific expression of a novel basic helix- loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.
PMID: 9079689 by Hogenesch J.B., et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.