Aquaporin-3 (AQP3)

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays a significant role in regulating SC (stratum corneum) and epidermal glycerol content.

Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may be a water and urea exit mechanism in antidiuresis in collecting duct cells.