This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
1 Citations
1 Citations 6 Q&As
Facts about Carbonic anhydrase 3.
Human | |
---|---|
Gene Name: | CA3 |
Uniprot: | P07451 |
Entrez: | 761 |
Belongs to: |
---|
alpha-carbonic anhydrase family |
CA3; CAIII; CA-III; Car3; Carbonate dehydratase III; carbonic anhydrase 3; Carbonic Anhydrase III; carbonic anhydrase III, muscle specific; EC 4.2.1.1
Mass (kDA):
29.557 kDA
Human | |
---|---|
Location: | 8q21.2 |
Sequence: | 8; NC_000008.11 (85438859..85449040) |
Muscle specific.
Cytoplasm.
Think about using the boster Bio anti-CD40/Cd40 antibody Picoband for your next research. Boster bio also offers Anti-AMPD3 or Anti Leukosialin SPN anti-leu SPN antibodies. These antibodies have been designed to be used in research labs. Boster Bio's signature products are antibodies, ELISA kit kits, and other molecular biological products. Boster Bio also provides a range of services for scientists. Boster Bio's customer service representatives are on hand all day long to help you with your purchase. Additionally, the company provides free technical resources and a support team to assist you with your project.
Paulie and her colleagues discovered the antigen CD40/Cd40. in 1985, on bladder cancer cells. It has since been thoroughly examined. It is now recognized as a major player in T-dependent B cell responses. In 1992, a closely related cell, CD154, was discovered and is mostly expressed on activated CD4 T lymphocytes. CD40 interactions with ligands are vital for isotype switching and germinal center development.
A vaccine containing anti-CD40/Cd40-derived antigens may be more effective than a conventional DC-specific immunotherapy. The anti-CD40/Cd40L form is an alternative to DC-targeting and does not require an adjuvant. Both formats can trigger protective T-cell responses in patients.
The anti-CD40/Cd40 antigen can be used as a potent vaccine to treat HIV infection. It recognizes dendritic cells. In addition, it works by activating a powerful immune response. Anti-CD40/Cd40 antibodies may be fusion proteins that are a part of Gag p17–Nef–Gag (GNG).
KPL-404, an anti CD40/Cd40 antibody , binds to the CD40 protein in human cells. This antibody also stained total CD19+ B cells, CD3+ T cells and non-T/B cells. It bound approximately 15% of non-T/B cell. It is noteworthy that the majority of these cells were CD14+ monoocytes.
This antibody against CD40/Cd40, which is based on the CA3 marker, can be used to examine samples of blood and tumors. It is highly effective for determining the presence of tumor cells and also highly specific and high-affinity. It has been employed in a variety of clinical settings, including to detect different diseases.
KPL-404 and G28-5 bind CD40 at the B cell's surface. However, they do not internalize cells. G28-5 shows partial internalization of CD40. These antibodies could be used in the treatment of autoimmune diseases as well as cancer immunotherapy. But, this is an ongoing study. The results prove that it is essential to determine if anti-CD40 mAbs can be effective against tumors.
Many autoimmune diseases, including SjS are connected to interactions between CD40 and CD40L. This pathogenic pathway is triggered by the production pathogenic autoantibodies. Numerous studies have shown that certain polymorphisms within CD40 proteins increase the likelihood of developing SLE and Graves' disease. Additionally, CD40-CD40L interactions can lead to the formation of GCs inside salivary glands in SjS.
The anti-CD40/Cd40 fusion protein is extremely active in human B cells as well as MDDCs. These experiments showed that the anti-CD40-Picoband anti-CD40L fusion protein strongly increased the proliferation of human B cells as compared to the cell group that was not treated. These results were normalized to maximize B cell proliferation.
Seattle Genetics developed the CD40-PEP mAb. It has been tested in phase I studies in patients with multiple myeloma and non-Hodgkin's lymphoma. The antibody induces apoptosis in malignant B cells and inhibits tumor growth in human xenograft models. It was also examined in the phase I study of patients who had relapsed NHL patients.
Ampd3 is a transmembrane-related protein that facilitates the conversion of AMP to IMP. Adenylosuccinate synthase (AS) is one of the genes found in erythrocytes can convert IMP to AMP again. The erythrocytes of mice and humans lack this enzyme. AMPD3 is normally suppressed in human RBCs, leading to anemia or hemolysis. This is alleviated by the MRI49372 mutation.
AMPD3 is a 90kDa protein that contains 767 amino acids. It is also highly regulated. This enzyme is a branch of the Adenylate Catabolic Pathway that leads to inosine monphosphate. It is found in many tissues, including the brain. Anti-AMPD3 antibodies target this particular branch point. These results are consistent with those of other AMPD3 antibody.
In addition to human malaria, human disease-associated diseases may result in shorter half-life of RBCs, including sickle cell disease and thalassemia. These conditions can cause the reduction of RBC half-life. AMPD3 activation improves the resistance to infection by P. chabaudi. The short RBC half-life of the mice deficient in Ampd3 could be the reason for the low parasitemia in those suffering from the condition. Mice affected by Ampd3 T689A mutations lose nearly a quarter of their RBCs daily. Infection with malaria can exacerbate the loss.
Boster Bio has a polyclonal antibody for Leukosialin (SPN) that can be used in immunoassays. This antibody is validated for IHC WB, IHC and Flow applications and has been proven to react with the recombinant proteins. The antibodies have been tested against a panel of 250 tissues. Boster Bio also provides antibodies that have been validated quantitatively against recombinant proteins and non-transfected cell lines.
The large sialoglycoprotein SPN encoded by the SPN gene is encoded by the SPN gene. It is an important component of the immune system. Deficiency in it can cause illnesses such as Wiscott-Aldrich syndrome. Additionally, it could be involved in activation of T-cells which involves the elimination of CD43 from the immunologic synapse, so that TCRs are able to effectively interact with APC.
Boster Bio Anti-CD43/SPN Monoclonal Antibody is part of the Picoband(tm) catalog. It has been tested for FC and Flow Cytometry and shows specificity against Human, Mouse and Rat CD43. Anti-Leukosialin in Boster Bio can be purchased in a 1.0mg/ml dose.
PMID: 3086182 by Lloyd J., et al. Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase.
PMID: 3099285 by Wade R., et al. Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.
*More publications can be found for each product on its corresponding product page