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- Table of Contents
CD33 Antibodies
AND CD33 ELISA kits, CD33 Proteins
Many biological assays use antibodies to detect CD33, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD33 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD33 antibodies...
Designing a Western blot for CD33? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CD33 Western Blot GuideCD33 Infographic by Boster Bio
All CD33 Products
Product
Figures
Specificity
Applications
Price
Anti-PI3K-gamma/PIK3CG Antibody Picoband®
8 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01517-2
100 μg/vial
Cat # A01517-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01516-1
100 μg/vial
Cat # A01516-1
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00231-5
100 μg
Cat # M00231-5
100 μg
Anti-NCR1 Antibody
1 Citations
Human, Mouse
ELISA, Flow Cytometry, IHC
$370
Cat # A01516-2
100 μg/vial
Cat # A01516-2
100 μg/vial
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-9
100 μg
Cat # M01508-9
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-3
100 μg
Cat # M01508-3
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00769-3
100 μg
Cat # M00769-3
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00231-4
100 μg
Cat # M00231-4
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00200-5
100 μg
Cat # M00200-5
100 μg
Human, Primate
Flow Cytometry, IP, IHC-F, ICC, WB, CyTOF
$299
Cat # M01508-1
0.1 mg
Cat # M01508-1
0.1 mg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-8
100 μg
Cat # M01508-8
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-7
100 μg
Cat # M01508-7
100 μg
Human, Mouse, Rat
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-6
100 μg
Cat # M01508-6
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-4
100 μg
Cat # M01508-4
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00926-5
100 μg
Cat # M00926-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01508-5
100 μg
Cat # M01508-5
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M14323-2
100 μg
Cat # M14323-2
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M14323-1
100 μg
Cat # M14323-1
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M14323
100 μg
Cat # M14323
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00200-6
100 μg
Cat # M00200-6
100 μg
Human, Mouse
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M00098-4
100 μg
Cat # M00098-4
100 μg
CD33 Overview
Facts about Myeloid cell surface antigen CD33.
Myeloid cell surface antigen CD33 (CD33)
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:15597323, PubMed:11320212). Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid- bearing glycans (PubMed:7718872).
Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine- based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK (PubMed:28325905, PubMed:10887109). These phosphorylations provide docking sites for the recruitment and activation of protein- tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10556798, PubMed:10206955, PubMed:10887109).
Gene Information
| Human | |
|---|---|
| Gene Name: | CD33 |
| Uniprot: | P20138 |
| Entrez: | 945 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CD33 antigen (gp67); CD33 antigen; CD33 molecule; CD33; FLJ00391; gp67; myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; Sialic acid-binding Ig-like lectin 3; Siglec3; Siglec-3; SIGLEC3gp67
Molecular Weight
Mass (kDA):
39.825 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.41 |
| Sequence: | 19; NC_000019.10 (51211054..51240016) |
Tissue Specificity
Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Subcellular Localizations
[Isoform CD33M]: Cell membrane; Single-pass type I membrane protein.; [Isoform CD33m]: Peroxisome. CD33m isoform does not localize to cell surfaces but instead accumulates in peroxisomes.
Diseases
- Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Acute Lymphocytic Leukemia
- Neoplasms
- Acute Leukemia
- Malignant Neoplasms
- Cytogenetic Abnormality
- Acute Promyelocytic Leukemia
- Myeloid Leukemia, Chronic
- Dysmyelopoietic Syndromes
- Lymphoma
Interacting Proteins
- KRT31
- KRT40
- PTPN11
- PTPN6
- S100A9
Pathways
- Cell Differentiation
- Cell Growth
- Pathogenesis
- Cell Proliferation
- Cell Cycle
- Cell Adhesion
- Cell Death
- Secretion
- Cytokine Production
- Localization
- Interphase
- Phagocytosis
- Inflammatory Response
PTMs
- Phosphorylation
- Glycosylation
- Cleavage
- Methylation
- Acetylation
Research Areas
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD33
bosterbio.com/bosterbio-gene-info-cards/CD33
References
PMID: 3139766 by Simmons D., et al. Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.
PMID: 11943481 by Yousef G.M., et al. Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes.
10 Publications of Boster CD33 Antibodies & ELISA Kits
- PubMed ID: 10.3892/mmr.2021.11938, Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats v...
- PubMed ID: 10.1111/aor.13622, Avβ3 single‐stranded DNA aptamer attenuates vascular restenosis via Ras‐PI3...
- PubMed ID: 10.1016/j.jare.2021.09.001, A comparative study of Mesenchymal Stem Cells transplantation approach to antago...
- PubMed ID: 10.1016/j.envpol.2021.116556, Mechanisms underlying reproductive toxicity induced by nickel nanoparticles iden...
- PubMed ID: 33649809, Nie L,Liu M,Chen J,Wu Q,Li Y,Yi J,Zheng X,Zhang J,Chu C,Yang J.Hydrogen sulfide ...
- PubMed ID: 33654381, Xu Y,Chen W,Chen Z,Huang M,Yang F,Zhang Y.Mechanism of Action of Xiaoyao San in ...
- PubMed ID: -, Lu Kong,Yongya Wu,Wangcheng Hu,Lin Liu,Yuying Xue,Geyu Liang,Mechanisms underlyi...
- PubMed ID: 32990282, Han F,Xu H,Shen JX,Pan C,Yu ZH,Chen JJ,Zhu XL,Cai YF,Lu YP.RhoA/Rock2/Limk1/cofi...
- PubMed ID: 33382670, Chen H,Sheng H,Zhao Y,Zhu G.Piperine Inhibits Cell Proliferation and Induces Apo...
- PubMed ID: 32243998, Amin N,Xie S,Tan X,Chen Y,Ren Q,Botchway BOA,Hu S,Ma Y,Hu Z,Fang M.Optimized int...
*More publications can be found for each product on its corresponding product page