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- Table of Contents
CHD2 Antibodies
AND CHD2 ELISA kits, CHD2 Proteins
Many biological assays use antibodies to detect CHD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHD2 antibodies...
Designing a Western blot for CHD2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CHD2 Western Blot GuideCHD2 Infographic by Boster Bio
All CHD2 Products
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Specificity
Applications
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CHD2 Overview
Facts about Chromodomain-helicase-DNA-binding protein 2.
Chromodomain-helicase-DNA-binding protein 2 (CHD2)
DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by encouraging deposition of histone H3.3.
Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the beginning of myogenic gene expression, promoting their expression (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CHD2 |
| Uniprot: | O14647 |
| Entrez: | 1106 |
Family
| Belongs to: |
|---|
| SNF2/RAD54 helicase family |
Alternative Names
ATP-dependent helicase CHD2; CHD-2; chromodomain helicase DNA binding protein 2; chromodomain-helicase-DNA-binding protein 2; DKFZp547I1315; DKFZp686E01200; DKFZp781D1727; EC 3.6.1; EC 3.6.4.12; FLJ38614
Molecular Weight
Mass (kDA):
211.344 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q26.1 |
| Sequence: | 15; NC_000015.10 (92900324..93027996) |
Subcellular Localizations
Nucleus. Binds to myogenic gene promoters.
Diseases
- Neoplasms
- Charge Syndrome
- Malignant Neoplasms
- Lymphoma
- Congenital Abnormality
- Diabetes Mellitus
- Colorectal Cancer
- Cell Transformation, Neoplastic
- Learning Disorders
- Stomach Neoplasms
- Coronary Heart Disease
- Atresia
Interacting Proteins
- TEKT1
- THAP1
- TRIM41
Pathways
- Chromatin Remodeling
- Atp-dependent Chromatin Remodeling
- Cell Differentiation
- Pathogenesis
- Methylation
- Cell Adhesion
- Histone Deacetylation
- Hematopoietic Stem Cell Differentiation
- Stem Cell Differentiation
PTMs
- Cleavage
Research Areas
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHD2
bosterbio.com/bosterbio-gene-info-cards/CHD2
References
PMID: 9326634 by Woodage T., et al. Characterization of the CHD family of proteins.
PMID: 23708187 by Carvill G.L., et al. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.