COMT Antibodies

AND COMT ELISA kits, COMT Proteins

Many biological assays use antibodies to detect COMT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with COMT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop COMT antibodies...

We validate the specificity of these antibodies to COMT by testing them on tissues known to express COMT positively and negatively. Browse below to find the COMT antibody that suites your experiment. We have 9 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for COMT? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the COMT Western Blot Guide

COMT Infographic by Boster Bio

All COMT Products

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Product

Figures

Specificity

Applications

Price

Anti-COMT Antibody Picoband® (monoclonal, 15C10)

Western blot analysis of COMT using anti-COMT antibody (M00464)

IHC analysis of COMT using anti-COMT antibody (M00464)

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00464
100 μg/vial

Human COMT ELISA Kit PicoKine®

Human

ELISA

$750
Cat # EK1406
96 wells/kit, with removable strips.

Anti-LRTOMT Antibody Picoband®

IHC analysis of LRTOMT using anti-LRTOMT antibody (A13092-1)

Human, Mouse, Rat

IHC, WB

$370
Cat # A13092-1
100 μg/vial

Anti-COMT Antibody Picoband®

Western blot analysis of COMT using anti-COMT antibody (PB9539)

IHC analysis of COMT using anti-COMT antibody (PB9539)

Flow Cytometry analysis of U251 cells using anti-COMT antibody (PB9539)

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$370
Cat # PB9539
100 μg/vial

Anti-Pin1 Antibody Picoband® (monoclonal, 5E5)

Western blot analysis of Pin1 using anti-Pin1 antibody (M00467-1)

IF analysis of Pin1 using anti-Pin1 antibody (M00467-1)

Flow Cytometry analysis of U87 cells using anti-Pin1 antibody (M00467-1)

Human, Monkey, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M00467-1
100 μg/vial

COMT (NM_000754) Human Over-expression Lysate

Human

$628
Cat # LS001312
20 µg, 100 µg

COMTD1 (NM_144589) Human Over-expression Lysate

Human

$628
Cat # LS118881
20 µg, 100 µg

Anti-COMT Rabbit Monoclonal Antibody

All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature

Human, Mouse, Rat

IHC, WB

$370
Cat # M00464-2
100 μl/vial

Human COMT Recombinant Protein

SDS-PAGE

$300
Cat # PROTP21964
Starting from 20ug

COMT Overview

Facts about Catechol O-methyltransferase.

COMT 3D structure. Source: alphafold

Catechol O-methyltransferase (COMT)

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive medications, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Gene Information

Human
Gene Name:	COMT
Uniprot:	P21964
Entrez:	1312

Family

Belongs to:

class I-like SAM-binding methyltransferase superfamily

Alternative Names

catechol O-methyltransferase; catechol-O-methyltransferase; COMT; EC 2.1.1.6

Molecular Weight

Mass (kDA):
30.037 kDA

Genomic Context


Human

Location:	22q11.21
Sequence:	22; NC_000022.11 (19941772..19969975)

Tissue Specificity

Brain, liver, placenta, lymphocytes and erythrocytes.

Subcellular Localizations

[Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.

Diseases

Parkinson Disease
Schizophrenia
Malignant Neoplasms
Depressive Disorder
Malignant Neoplasm Of Breast
Mental Disorders
Psychotic Disorders
Mammary Neoplasms
Pain
Bipolar Disorder
Dyskinetic Syndrome
Anxiety Disorders
Attention Deficit Hyperactivity Disorder

Nervousness
Cognition Disorders
Dysequilibrium Syndrome
Malnutrition
Digeorge Syndrome
Major Depressive Disorder
Neoplasms

Interacting Proteins

CDC27
KRT31
KRT40
KRTAP5-9
TRIP13

Pathways

Methylation
Cognition
Pathogenesis
Transport
Excretion
Localization
Conjugation
Secretion
Aging
Translation
Cell Proliferation
Prepulse Inhibition

Brain Development
Menopause
Menarche
Natriuresis
Sulfation
Dna Repair
Dna Methylation

PTMs

Methylation
Reduction
Oxidation
Deamination
Hydroxylation
Decarboxylation
Phosphorylation

Demethylation
Cleavage
Acetylation
Dephosphorylation
Sulphation
Iodination
Nitration

Biotinylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/COMT

References

PMID: 1707278 by Lundstroem K., et al. Cloning and characterization of human placental catechol-O- methyltransferase cDNA.

PMID: 1847521 by Bertocci B., et al. Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.