Anti-Catechol O-methyltransferase COMT Antibody

COMT antibody

Boster Bio Anti-Catechol O-methyltransferase COMT Antibody catalog # PA2203. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PA2203
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Catechol O-methyltransferase COMT Antibody

View all COMT Antibodies

SKU/Catalog Number

PA2203

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Catechol O-methyltransferase COMT Antibody catalog # PA2203. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Catechol O-methyltransferase COMT Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2203)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human COMT.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2203 is reactive to COMT in Human, Mouse, Rat

Applications

PA2203 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

28 kDa

Calculated molecular weight

30.037kDa

Background of COMT

Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat

Validation Images & Assay Conditions

Gene/Protein Information For COMT (Source: Uniprot.org, NCBI)

Gene Name

COMT

Full Name

Catechol O-methyltransferase

Weight

30.037kDa

Superfamily

class I-like SAM-binding methyltransferase superfamily

Alternative Names

catechol O-methyltransferase; catechol-O-methyltransferase; COMT; EC 2.1.1.6 COMT HEL-S-98n catechol-O-methyltransferase catechol O-methyltransferase|epididymis secretory sperm binding protein Li 98n|testicular tissue protein Li 42

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on COMT, check out the COMT Infographic

COMT infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for COMT: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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3 Customer Q&As for Anti-Catechol O-methyltransferase COMT Antibody

Question

Is this PA2203 anti-COMT antibody reactive to the isotypes of COMT?

Verified Customer

Verified customer

Asked: 2019-09-24

Answer

The immunogen of PA2203 anti-COMT antibody is A synthetic peptide corresponding to a sequence at the N-terminus of human COMT(94-108aa DKKGKIVDAVIQEHQ). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2019-09-24

Question

Our lab want to know about to test anti-COMT antibody PA2203 on human muscle skin for research purposes, then I may be interested in using anti-COMT antibody PA2203 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2019-06-21

Answer

The products we sell, including anti-COMT antibody PA2203, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2019-06-21

Question

I was wanting to use your anti-COMT antibody for IHC for human muscle skin on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human muscle skin identification?

J. Jha

Verified customer

Asked: 2015-12-24

Answer

As indicated on the product datasheet, PA2203 anti-COMT antibody has been validated for IHC, WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human muscle skin in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2015-12-24

Order DetailsPrice
PA2203

100μg

$370
PA2203-10ug

10μg sample (liquid)

$99
PA2203-Biotin

100 μg Biotin conjugated

$570
PA2203-Cy3

100 μg Cy3 conjugated

$570
PA2203-Dylight488

100 μg Dylight488 conjugated

$570
PA2203-Dylight550

100 μg Dylight550 conjugated

$570
PA2203-Dylight594

100 μg Dylight594 conjugated

$570
PA2203-FITC

100 μg FITC conjugated

$570
PA2203-HRP

100 μg HRP conjugated

$570
PA2203-APC

100 μg APC conjugated

$670
PA2203-PE

100 μg PE conjugated

$670
PA2203-carrier-free

Carrier Free

$370

More conjugates/formats

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PA2203
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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