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- Table of Contents
Cytochrome P450 2D6 Antibodies
AND CYP2D6 ELISA kits, Cytochrome P450 2D6 Proteins
Many biological assays use antibodies to detect Cytochrome P450 2D6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2D6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2D6 antibodies...
Designing a Western blot for Cytochrome P450 2D6? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP2D6 Western Blot GuideDesigning an IHC experiment for Cytochrome P450 2D6? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CYP2D6 IHC GuideCYP2D6 Infographic by Boster Bio
All CYP2D6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # A00498-1
100 μg/vial
Cat # A00498-1
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00498
100 μl
Cat # M00498
100 μl
Human
ELISA
$480
Cat # EKC1913
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1913
1 kit, containing one 96-well plate and all necessary reagents
CYP2D6 Overview
Facts about Cytochrome P450 2D6.
Cytochrome P450 2D6 (CYP2D6)
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It's involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP2D6 |
| Uniprot: | P10635 |
| Entrez: | 1565 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
CPD6P450DB1; CYP2D; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; CYP2DL1; CYPIID6; cytochrome P450 2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising); cytochrome P450, subfamily IID (debrisoquine, sparteine, etc.; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising); cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing); Cytochrome
Molecular Weight
Mass (kDA):
55.769 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.2 |
| Sequence: | 22; NC_000022.11 (42126499..42130810, complement) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Malignant Neoplasms
- Depressive Disorder
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasms
- Schizophrenia
- Pain
- Medication Reaction
- Parkinson Disease
- Hepatitis
- Carcinoma
- Mental Disorders
Pathways
- Excretion
- Demethylation
- Pathogenesis
- Transport
- Conjugation
- Translation
- Secretion
- Cell Proliferation
- Glomerular Filtration
- Cognition
- Dna Repair
- Serotonin Uptake
- Localization
PTMs
- Hydroxylation
- Demethylation
- Oxidation
- Acetylation
- Reduction
- Deamination
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2D6
bosterbio.com/bosterbio-gene-info-cards/CYP2D6
References
PMID: 3410476 by Gonzalez F.J., et al. Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
PMID: 3123997 by Gonzalez F.J., et al. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.