Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband®

Cytochrome P450 2D6 antibody

Boster Bio Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband® catalog # A00498-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Info Summary

SKU: A00498-1
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband®

View all Cytochrome P450 2D6 Antibodies

SKU/Catalog Number

A00498-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband® catalog # A00498-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00498-1)

Host

Rabbit

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Cytochrome P450 2D6.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

A00498-1 is reactive to CYP2D6 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

56 kDa

Calculated molecular weight

55769 MW

Background of Cytochrome P450 2D6

Cytochrome P450 2D6 (CYP2D6) is one of the most important enzymes involved in the metabolism of xenobiotics in the body. It is a member of Cytochrome P450, family 2, subfamily D, polypeptide 6. This gene is mapped to chromosome 22q13.1. It has got 497 amino acid proteins which shares 73% sequence identity with the rat protein. CYP2D6 is highly expressed in human liver and it is the major isozyme involved in the formation of N-hydroxyprocainamide, a metabolite potentially involved in the drug-induced lupus syndrome observed with procainamide.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A00498-1 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Mouse, Rat, Human

Positive Control

WB: rat liver tissue, mouse liver tissue
IHC: rat intestine tissue, mouse liver tissue, human liver cancer tissue, mouse intestine tissue

Validation Images & Assay Conditions

Gene/Protein Information For CYP2D6 (Source: Uniprot.org, NCBI)

Gene Name

CYP2D6

Full Name

Cytochrome P450 2D6

Weight

55769 MW

Superfamily

cytochrome P450 family

Alternative Names

Cytochrome P450 2D6;1.14.14.1;CYPIID6;Cytochrome P450-DB1;Debrisoquine 4-hydroxylase;CYP2D6;CYP2DL1; CYP2D6 CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450 family 2 subfamily D member 6 cytochrome P450 2D6|cholesterol 25-hydroxylase|cytochrome P450, family 2, subfamily D, polypeptide 6|cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2|cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2|cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6|cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1|cytochrome P450-DB1|debrisoquine 4-hydroxylase|flavoprotein-linked monooxygenase|microsomal monooxygenase|nonfunctional cytochrome P450 2D6|xenobiotic monooxygenase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CYP2D6, check out the CYP2D6 Infographic

CYP2D6 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CYP2D6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-Cytochrome P450 2D6/CYP2D6 Antibody Picoband®

Question

We are currently using anti-Cytochrome P450 2D6/CYP2D6 antibody A00498-1 for rat tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it likely that the antibody can work on feline tissues as well?

J. Krishna

Verified customer

Asked: 2015-07-14

Answer

The anti-Cytochrome P450 2D6/CYP2D6 antibody (A00498-1) has not been tested for cross reactivity specifically with feline tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2015-07-14

Order DetailsPrice
A00498-1

100μg

$370
A00498-1-10ug

10μg sample (liquid)

$99
A00498-1-Biotin

100 μg Biotin conjugated

$570
A00498-1-Cy3

100 μg Cy3 conjugated

$570
A00498-1-Dylight488

100 μg Dylight488 conjugated

$570
A00498-1-Dylight550

100 μg Dylight550 conjugated

$570
A00498-1-Dylight594

100 μg Dylight594 conjugated

$570
A00498-1-FITC

100 μg FITC conjugated

$570
A00498-1-HRP

100 μg HRP conjugated

$570
A00498-1-APC

100 μg APC conjugated

$670
A00498-1-PE

100 μg PE conjugated

$670
A00498-1-iFluor647

100 μg iFluor647 conjugated

$670
A00498-1-carrier-free

Carrier Free

$370

More conjugates/formats

Free Secondary Antibody

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A00498-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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